Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/118453
Title: APPLICATION OF CARBON NANOTUBES IN DRUG DELIVERY: TARGETING MITOCHONDRIA FOR CANCER THERAPY
Authors: YOONG SIA LEE
Keywords: Carbon Nanotubes, Drug Delivery, Cancer, Mitochondria, Nanocarrier, Targeted Delivery
Issue Date: 21-Aug-2014
Citation: YOONG SIA LEE (2014-08-21). APPLICATION OF CARBON NANOTUBES IN DRUG DELIVERY: TARGETING MITOCHONDRIA FOR CANCER THERAPY. ScholarBank@NUS Repository.
Abstract: Mitochondria emerge as intriguing targets as their physiological functions are altered in cancer. Numerous studies have illustrated potential of nanocarriers in delivering mitochondria-acting compounds. Carbon nanotubes (CNTs) are becoming prominent for drug delivery due to their unique shape which promotes cellular-uptake and large aspect-ratio that facilitates surface functionalization of bioactive molecules. In first part of the project, multi-walled carbon nanotubes (MWCNTs) were functionalized with mitochondria-targeting Rhodamine-110, yielding MWCNT-Rho. MWCNT-Rho was found to co-localize with mitochondria and potentiate the activity of its encapsulated cargo drug molecules. In second part of the project, MWCNTs was engineered to deliver an anti-cancer peptide targeting hexokinase II on mitochondria. All MWCNT-peptide conjugates were internalized intracellularly and found to be in the vicinity of mitochondria. Importantly, MWCNT-peptide conjugates induced hexokinase II release from mitochondria that resulted in apoptosis. In conclusion, MWCNTs could be a versatile nanocarrier for targeted delivery.
URI: http://scholarbank.nus.edu.sg/handle/10635/118453
Appears in Collections:Ph.D Theses (Open)

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