Please use this identifier to cite or link to this item: https://doi.org/10.1016/S0026-2862(03)00020-7
Title: Water immersion and EMLA cause similar digit skin wrinkling and vasoconstriction
Authors: Wilder-Smith, E. 
Chow, A.
Keywords: Autonomic function testing
EMLA
Humans
Vasoconstriction
Water immersion wrinkling
Issue Date: 2003
Citation: Wilder-Smith, E., Chow, A. (2003). Water immersion and EMLA cause similar digit skin wrinkling and vasoconstriction. Microvascular Research 66 (1) : 68-72. ScholarBank@NUS Repository. https://doi.org/10.1016/S0026-2862(03)00020-7
Abstract: Water immersion skin wrinkling tests limb sympathetic vasoconstrictor function. We have recently shown that water immersion wrinkling is accompanied by digit vasoconstriction and postulated that vasoconstriction is the main underlying mechanism. To test this further, we applied vasoconstrictive cream (EMLA) to the distal digit and compared the degree of skin wrinkling and digit blood flow reduction with those after water immersion. In 25 healthy volunteers (6 male, 19 female; mean age, 35 yr) subjected to EMLA and water immersion, both clinical wrinkling scores and reduction in digit blood flow (mean of 2.01 and 2.29 cm/s, respectively) were nearly identical. Control using aqueous cream resulted in minimal skin wrinkling and nonsignificant reduction in digit artery flow (P = 0.170). These data further support that water immersion skin wrinkling is mediated by vasoconstriction. The EMLA cream patch test may develop into a useful screening test for hand sympathetic vasoconstrictor function. © 2003 Elsevier Science (USA). All rights reserved.
Source Title: Microvascular Research
URI: http://scholarbank.nus.edu.sg/handle/10635/117962
ISSN: 00262862
DOI: 10.1016/S0026-2862(03)00020-7
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