Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.expneurol.2004.12.007
DC FieldValue
dc.titleModulation of parvalbumin expression in the motor cortex of parkinsonian rats
dc.contributor.authorCapper-Loup, C.
dc.contributor.authorBurgunder, J.-M.
dc.contributor.authorKaelin-Lang, A.
dc.date.accessioned2014-12-17T08:56:50Z
dc.date.available2014-12-17T08:56:50Z
dc.date.issued2005
dc.identifier.citationCapper-Loup, C., Burgunder, J.-M., Kaelin-Lang, A. (2005). Modulation of parvalbumin expression in the motor cortex of parkinsonian rats. Experimental Neurology 193 (1) : 234-237. ScholarBank@NUS Repository. https://doi.org/10.1016/j.expneurol.2004.12.007
dc.identifier.issn00144886
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/117779
dc.description.abstractDopamine deficiency in Parkinson's disease leads to numerous molecular changes in basal ganglia. However, the consequences of these changes on the motor cortex remain unclear. Here we show that the immunoreactivity of parvalbumin, which is expressed in GABAergic interneurons, increases in the primary motor cortex of parkinsonian rats. This increase can be reversed by a subsequent lesion of the subthalamic nucleus. These results suggest that dopamine deficiency induces reversible changes in GABAergic cortical cells, which might be linked with parkinsonian symptoms. © 2004 Elsevier Inc. All rights reserved.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.expneurol.2004.12.007
dc.sourceScopus
dc.subject6-Hydroxydopamine
dc.subjectGABAergic system
dc.subjectImmunohistochemistry
dc.subjectIntracortical inhibition
dc.subjectParvalbumin
dc.subjectRat
dc.typeArticle
dc.contributor.departmentMEDICINE
dc.description.doi10.1016/j.expneurol.2004.12.007
dc.description.sourcetitleExperimental Neurology
dc.description.volume193
dc.description.issue1
dc.description.page234-237
dc.description.codenEXNEA
dc.identifier.isiut000228413300023
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