Please use this identifier to cite or link to this item: https://doi.org/10.1016/S0002-9343(03)00353-X
Title: Epidemiology of respiratory viruses in patients hospitalized with near-fatal asthma, acute exacerbations of asthma, or chronic obstructive pulmonary disease
Authors: Tan, W.C. 
Xiang, X. 
Qiu, D. 
Ng, T.P. 
Lam, S.F.
Hegele, R.G.
Issue Date: 2003
Citation: Tan, W.C., Xiang, X., Qiu, D., Ng, T.P., Lam, S.F., Hegele, R.G. (2003). Epidemiology of respiratory viruses in patients hospitalized with near-fatal asthma, acute exacerbations of asthma, or chronic obstructive pulmonary disease. American Journal of Medicine 115 (4) : 272-277. ScholarBank@NUS Repository. https://doi.org/10.1016/S0002-9343(03)00353-X
Abstract: Purpose: We compared the prevalence and spectrum of common respiratory viruses among patients with near-fatal asthma, acute exacerbations of asthma, or chronic obstructive pulmonary disease (COPD), and the relation of these findings to acute respiratory symptoms. Methods: We obtained adequate samples of respiratory secretions from 17 patients hospitalized with near-fatal asthma, 29 with acute asthma, and 14 with COPD. We used a polymerase chain reaction-based method to test for six common respiratory viruses in samples from endotracheal tube aspirates from patients with near-fatal asthma, and from induced sputum specimens from patients with acute asthma or COPD. Respiratory symptoms (runny nose, sore throat, fever, chills, malaise, and cough) were recorded. Quiescent-phase induced sputum specimens were examined from patients who were initially virus positive. Results: Viral nucleic acids were detected in 52% (31/60) of acute-phase specimens and 7% (2/29) of quiescent-phase specimens examined (P <0.001), with similar proportions of virus-positive patients during the acute phase in the three groups: 59% (10/17) of those with near-fatal asthma, 41% (12/29) with acute asthma, and 64% (9/14) with COPD. Picornavirus (47% [n = 8]) and adenovirus (24% [n = 4]) were most commonly identified in near-fatal asthma, whereas influenza virus (36% [n = 5]) predominated in COPD. Virus-positive patients had a significantly increased frequency of runny nose, sore throat, fever, chills, and malaise (odds ratio = 4.1 to 18; P = 0.02 to 0.001). Conclusion: Respiratory viruses are associated with hospitalizations for near-fatal asthma, acute asthma, and COPD, with some differences in the spectrum of viruses involved in the different groups of patients. Respiratory viruses are a target for the prevention and perhaps the treatment of these conditions. © 2003 by Excerpta Medica Inc.
Source Title: American Journal of Medicine
URI: http://scholarbank.nus.edu.sg/handle/10635/117663
ISSN: 00029343
DOI: 10.1016/S0002-9343(03)00353-X
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

120
checked on Aug 21, 2019

WEB OF SCIENCETM
Citations

101
checked on Aug 13, 2019

Page view(s)

52
checked on Aug 16, 2019

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.