Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.jocn.2003.10.020
Title: Acute ophthalmoplegia with pupillary areflexia associated with anti-GQ1b antibody
Authors: Chan, Y.C.
Wilder-Smith, E. 
Chee, M.W.L.
Keywords: anti-GQ1b IgG antibody
areflexia
ataxia
external ophthalmoplegia
Guillain-Barre syndrome
internal ophthalmoplegia
Miller Fisher syndrome
Issue Date: 2004
Citation: Chan, Y.C., Wilder-Smith, E., Chee, M.W.L. (2004). Acute ophthalmoplegia with pupillary areflexia associated with anti-GQ1b antibody. Journal of Clinical Neuroscience 11 (6) : 658-660. ScholarBank@NUS Repository. https://doi.org/10.1016/j.jocn.2003.10.020
Abstract: Raised anti-GQ1b antibody is associated with Miller Fisher syndrome, Guillain-Barre syndrome (GBS) with ophthalmoplegia, Bickerstaff's brain stem encephalitis, acute ophthalmoparesis without ataxia and ataxic GBS without opthalmoplegia. We report a rare case of acute ophthalmoplegia associated with anti-GQ1b antibody that also had pupillary areflexia. A 35-year-old Chinese lady presented with external ophthalmoplegia, pupillary areflexia and no other abnormalities of cranial nerves, muscle tone, deep tendon reflexes, limb power or cerebellar dysfunction. Anti-GQ1b IgG antibody titre was significantly elevated, while neuroimaging of brain and orbital structures, nerve conduction study and cerebral spinal fluid examination were normal. Pupillary areflexia should be recognized as another feature that may be present in conditions associated with raised anti-GQ1b antibody. © 2004 Elsevier Ltd. All rights reserved.
Source Title: Journal of Clinical Neuroscience
URI: http://scholarbank.nus.edu.sg/handle/10635/117541
ISSN: 09675868
DOI: 10.1016/j.jocn.2003.10.020
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