Please use this identifier to cite or link to this item: https://doi.org/10.2217/fon.12.53
Title: Pharmacologic modulation strategies to reduce dose requirements of anticancer therapy while preserving clinical efficacy
Authors: Zee, Y.-K.
Goh, B.-C.
Lee, S.-C. 
Keywords: drug interactions
drug transporters
drug-metabolizing enzymes
inducers
inhibitors
pharmacokinetic interactions
pharmacologic modulation
Issue Date: Jun-2012
Citation: Zee, Y.-K., Goh, B.-C., Lee, S.-C. (2012-06). Pharmacologic modulation strategies to reduce dose requirements of anticancer therapy while preserving clinical efficacy. Future Oncology 8 (6) : 731-749. ScholarBank@NUS Repository. https://doi.org/10.2217/fon.12.53
Abstract: Drug interactions may be exploited to overcome pharmacokinetic issues in order to improve the therapeutic index of a drug, with clinical goals of reducing the dose of the active drug while preserving efficacy or reducing toxicity. This strategy has been used in infectious disease and transplant medicine, and, more recently, in oncology. Pharmacologic modulation strategies range from coadministration of either a drug that inhibits a metabolizing enzyme that would inactivate the drug of interest, a drug that induces an enzyme that activates the drug of interest or a drug that inhibits transporters that affect the uptake or elimination of the drug of interest. This review will discuss pharmacologic modulation strategies that have been tested clinically in order to increase systemic drug exposure. Important examples include ketoconazole inhibition of hepatic CYP3A4 in order to increase systemic exposure to docetaxel, irinotecan and etoposide, and cyclosporine inhibition of intestinal ATP-binding cassette transporters in order to decrease the toxicity of irinotecan and increase the bioavailability of oral docetaxel, paclitaxel and topotecan. © 2012 Future Medicine Ltd.
Source Title: Future Oncology
URI: http://scholarbank.nus.edu.sg/handle/10635/117353
ISSN: 14796694
DOI: 10.2217/fon.12.53
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

5
checked on May 4, 2021

WEB OF SCIENCETM
Citations

5
checked on Apr 26, 2021

Page view(s)

122
checked on May 2, 2021

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.