Please use this identifier to cite or link to this item: https://doi.org/10.1242/dev.071209
Title: Epithelial-mesenchymal transitions: Insights from development
Authors: Lim, J.
Thiery, J.P. 
Keywords: Epithelial-mesenchymal transition
Gastrulation
Heart morphogenesis
Neural crest
Issue Date: 1-Oct-2012
Citation: Lim, J., Thiery, J.P. (2012-10-01). Epithelial-mesenchymal transitions: Insights from development. Development (Cambridge) 139 (19) : 3471-3486. ScholarBank@NUS Repository. https://doi.org/10.1242/dev.071209
Abstract: Epithelial-mesenchymal transition (EMT) is a crucial, evolutionarily conserved process that occurs during development and is essential for shaping embryos. Also implicated in cancer, this morphological transition is executed through multiple mechanisms in different contexts, and studies suggest that the molecular programs governing EMT, albeit still enigmatic, are embedded within developmental programs that regulate specification and differentiation. As we review here, knowledge garnered from studies of EMT during gastrulation, neural crest delamination and heart formation have furthered our understanding of tumor progression and metastasis. © 2012. Published by The Company of Biologists Ltd.
Source Title: Development (Cambridge)
URI: http://scholarbank.nus.edu.sg/handle/10635/117347
ISSN: 09501991
DOI: 10.1242/dev.071209
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