Please use this identifier to cite or link to this item: https://doi.org/10.1002/bies.201200144
DC FieldValue
dc.titleMulti-step down-regulation of the secretory pathway in mitosis: A fresh perspective on protein trafficking
dc.contributor.authorYeong, F.M.
dc.date.accessioned2014-12-12T08:01:20Z
dc.date.available2014-12-12T08:01:20Z
dc.date.issued2013-05
dc.identifier.citationYeong, F.M. (2013-05). Multi-step down-regulation of the secretory pathway in mitosis: A fresh perspective on protein trafficking. BioEssays 35 (5) : 462-471. ScholarBank@NUS Repository. https://doi.org/10.1002/bies.201200144
dc.identifier.issn02659247
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/117084
dc.description.abstractThe secretory pathway delivers proteins synthesized at the rough endoplasmic reticulum (RER) to various subcellular locations via the Golgi apparatus. Currently, efforts are focused on understanding the molecular machineries driving individual processes at the RER and Golgi that package, modify and transport proteins. However, studies are routinely performed using non-dividing cells. This obscures the critical issue of how the secretory pathway is affected by cell division. Indeed, several studies have indicated that protein trafficking is down-regulated during mitosis. Moreover, the RER and Golgi apparatus exhibit gross reorganization in mitosis. Here I provide a relatively neglected perspective of how the mitotic cyclin-dependent kinase (CDK1) could regulate various stages of the secretory pathway. I highlight several aspects of the mitotic control of protein trafficking that remain unresolved and suggest that further studies on how the mitotic CDK1 influences the secretory pathway are necessary to obtain a deeper understanding of protein transport. © 2013 WILEY Periodicals, Inc.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1002/bies.201200144
dc.sourceScopus
dc.subjectCDK1
dc.subjectCell division cycle
dc.subjectEndoplasmic reticulum
dc.subjectGolgi
dc.subjectMitosis
dc.subjectProtein trafficking
dc.typeArticle
dc.contributor.departmentINSTITUTE OF MOLECULAR & CELL BIOLOGY
dc.description.doi10.1002/bies.201200144
dc.description.sourcetitleBioEssays
dc.description.volume35
dc.description.issue5
dc.description.page462-471
dc.description.codenBIOEE
dc.identifier.isiut000317668100012
Appears in Collections:Staff Publications

Show simple item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

10
checked on Jan 19, 2022

WEB OF SCIENCETM
Citations

10
checked on Jan 19, 2022

Page view(s)

103
checked on Jan 20, 2022

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.