Please use this identifier to cite or link to this item: https://doi.org/10.1016/B978-0-12-417136-7.00016-1
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dc.titleMicrofabricated Environments to Study Collective Cell Behaviors
dc.contributor.authorVedula, S.R.K.
dc.contributor.authorRavasio, A.
dc.contributor.authorAnon, E.
dc.contributor.authorChen, T.
dc.contributor.authorPeyret, G.
dc.contributor.authorAshraf, M.
dc.contributor.authorLadoux, B.
dc.date.accessioned2014-12-12T08:01:12Z
dc.date.available2014-12-12T08:01:12Z
dc.date.issued2014
dc.identifier.citationVedula, S.R.K., Ravasio, A., Anon, E., Chen, T., Peyret, G., Ashraf, M., Ladoux, B. (2014). Microfabricated Environments to Study Collective Cell Behaviors. Methods in Cell Biology 120 : 235-252. ScholarBank@NUS Repository. https://doi.org/10.1016/B978-0-12-417136-7.00016-1
dc.identifier.issn0091679X
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/117074
dc.description.abstractCoordinated cell movements in epithelial layers are essential for proper tissue morphogenesis and homeostasis. Microfabrication techniques have proven to be very useful for studies of collective cell migration in vitro. In this chapter, we briefly review the use of microfabricated substrates in providing new insights into collective cell behaviors. We first describe the development of micropatterned substrates to study the influence of geometrical constraints on cell migration and coordinated movements. Then, we present an alternative method based on microfabricated pillar substrates to create well-defined gaps within cell sheets and study gap closure. We also provide a discussion that presents possible pitfalls and sheds light onto the important parameters that allow the study of long-term cell culture on substrates of well-defined geometries. © 2014 Elsevier Inc.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/B978-0-12-417136-7.00016-1
dc.sourceScopus
dc.subjectCollective cell behavior
dc.subjectEpithelial gap closure
dc.subjectGeometrical constraints
dc.subjectMicrocontact printing
dc.subjectMicrofabricated substrates
dc.typeArticle
dc.contributor.departmentMECHANOBIOLOGY INSTITUTE
dc.description.doi10.1016/B978-0-12-417136-7.00016-1
dc.description.sourcetitleMethods in Cell Biology
dc.description.volume120
dc.description.page235-252
dc.identifier.isiut000332260400017
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