Please use this identifier to cite or link to this item: https://doi.org/10.1242/jcs.126367
Title: Loss of Git2 induces epithelial-mesenchymal transition by miR146a-Cnot6L-controlled expression of Zeb1
Authors: Zhou, W.
Thiery, J.P. 
Keywords: EMT
Git2
MiR-146a
Zeb1
Issue Date: Jun-2013
Citation: Zhou, W., Thiery, J.P. (2013-06). Loss of Git2 induces epithelial-mesenchymal transition by miR146a-Cnot6L-controlled expression of Zeb1. Journal of Cell Science 126 (12) : 2740-2746. ScholarBank@NUS Repository. https://doi.org/10.1242/jcs.126367
Abstract: Epithelial-mesenchymal transition (EMT) can be induced by several pleiotropically activated transcription factors, including the zincfinger E-box-binding protein Zeb1. Mechanisms regulating Zeb1 expression have been partly uncovered, showing a critical role for the miR-200 family members. In the present study, we show that Zeb1 is regulated by the Arf GTPase-activating protein (GAP) Git2. Following the loss of Git2, we found that miR-146a maturation is enhanced, which in turn promotes the expression of Zeb1 and induction of EMT. Furthermore, we found that Cnot6L, a validated target of miR-146a, affects the stability of Zeb1 mRNA through its deadenylase activity. Our results present evidence for a new role for loss of Git2 in promoting EMT through a novel regulatory pathway. © 2013. Published by The Company of Biologists Ltd.
Source Title: Journal of Cell Science
URI: http://scholarbank.nus.edu.sg/handle/10635/117065
ISSN: 00219533
DOI: 10.1242/jcs.126367
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

8
checked on Oct 14, 2019

WEB OF SCIENCETM
Citations

7
checked on Oct 7, 2019

Page view(s)

38
checked on Oct 11, 2019

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.