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|Title:||Loss of Git2 induces epithelial-mesenchymal transition by miR146a-Cnot6L-controlled expression of Zeb1||Authors:||Zhou, W.
|Issue Date:||Jun-2013||Citation:||Zhou, W., Thiery, J.P. (2013-06). Loss of Git2 induces epithelial-mesenchymal transition by miR146a-Cnot6L-controlled expression of Zeb1. Journal of Cell Science 126 (12) : 2740-2746. ScholarBank@NUS Repository. https://doi.org/10.1242/jcs.126367||Abstract:||Epithelial-mesenchymal transition (EMT) can be induced by several pleiotropically activated transcription factors, including the zincfinger E-box-binding protein Zeb1. Mechanisms regulating Zeb1 expression have been partly uncovered, showing a critical role for the miR-200 family members. In the present study, we show that Zeb1 is regulated by the Arf GTPase-activating protein (GAP) Git2. Following the loss of Git2, we found that miR-146a maturation is enhanced, which in turn promotes the expression of Zeb1 and induction of EMT. Furthermore, we found that Cnot6L, a validated target of miR-146a, affects the stability of Zeb1 mRNA through its deadenylase activity. Our results present evidence for a new role for loss of Git2 in promoting EMT through a novel regulatory pathway. © 2013. Published by The Company of Biologists Ltd.||Source Title:||Journal of Cell Science||URI:||http://scholarbank.nus.edu.sg/handle/10635/117065||ISSN:||00219533||DOI:||10.1242/jcs.126367|
|Appears in Collections:||Staff Publications|
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