Please use this identifier to cite or link to this item:
|Title:||Endoscopic tri-modal imaging improves detection of gastric intestinal metaplasia among a high-risk patient population in Singapore||Authors:||So, J.
|Issue Date:||Dec-2013||Citation:||So, J., Rajnakova, A., Chan, Y.-H., Tay, A., Shah, N., Salto-Tellez, M., Teh, M., Noriya, U. (2013-12). Endoscopic tri-modal imaging improves detection of gastric intestinal metaplasia among a high-risk patient population in Singapore. Digestive Diseases and Sciences 58 (12) : 3566-3575. ScholarBank@NUS Repository. https://doi.org/10.1007/s10620-013-2843-2||Abstract:||Background: Detection of pre-neoplastic gastric mucosal changes and early gastric cancer (EGC) by white-light endoscopy (WLE) is often difficult. In this study we investigated whether combined autofluorescence imaging (AFI) and narrow band imaging (NBI) can improve detection of pre-neoplastic lesions and early gastric cancer in high-risk patients. Patients and Methods: Chinese patients who were 50-years-old or above with dyspepsia were examined by both high-resolution WLE and combined AFI followed by NBI (AFI-NBI), consecutively in a prospective randomized cross-over setting, by two experienced endoscopists. The primary outcome was diagnostic ability of the two methods for patients with pre-neoplastic lesions such as intestinal metaplasia (IM) and mucosal atrophy. Results: Sixty-five patients were recruited. One patient with large advanced gastric cancer was found and excluded from the analysis. Among the remaining 64 patients, 38 (59 %) had IM; of these, 26 (68 %) were correctly identified by AFI-NBI (sensitivity 68 %, specificity 23 %) and only 13 (34 %) by WLE (sensitivity 34 %, specificity 65 %). AFI-NBI detected more patients with IM than did WLE (p = 0.011). Thirty-one patients (48 %) had mucosal atrophy. Ten patients (32 %) were identified by AFI-NBI (sensitivity 32 %, specificity 79 %) and four patients (13 %) by WLE (sensitivity 13 %, specificity 88 %) (p = 0.100). No dysplasia or EGC was found. Conclusion: AFI-NBI identified significantly more patients with IM than did WLE. Our result warrants further studies to define the role of combined AFI-NBI endoscopy for detection of precancerous conditions. © 2013 Springer Science+Business Media New York.||Source Title:||Digestive Diseases and Sciences||URI:||http://scholarbank.nus.edu.sg/handle/10635/117000||ISSN:||01632116||DOI:||10.1007/s10620-013-2843-2|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on May 3, 2021
WEB OF SCIENCETM
checked on May 3, 2021
checked on May 2, 2021
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.