Please use this identifier to cite or link to this item: https://doi.org/10.1182/blood-2011-07-364224
DC FieldValue
dc.titleDysregulated microRNAs affect pathways and targets of biologic relevance in nasal-type natural killer/T-cell lymphoma
dc.contributor.authorNg, S.-B.
dc.contributor.authorYan, J.
dc.contributor.authorHuang, G.
dc.contributor.authorSelvarajan, V.
dc.contributor.authorTay, J.L.-S.
dc.contributor.authorLin, B.
dc.contributor.authorBi, C.
dc.contributor.authorTan, J.
dc.contributor.authorKwong, Y.-L.
dc.contributor.authorShimizu, N.
dc.contributor.authorAozasa, K.
dc.contributor.authorChng, W.-J.
dc.date.accessioned2014-12-12T08:00:05Z
dc.date.available2014-12-12T08:00:05Z
dc.date.issued2011-11-03
dc.identifier.citationNg, S.-B., Yan, J., Huang, G., Selvarajan, V., Tay, J.L.-S., Lin, B., Bi, C., Tan, J., Kwong, Y.-L., Shimizu, N., Aozasa, K., Chng, W.-J. (2011-11-03). Dysregulated microRNAs affect pathways and targets of biologic relevance in nasal-type natural killer/T-cell lymphoma. Blood 118 (18) : 4919-4929. ScholarBank@NUS Repository. https://doi.org/10.1182/blood-2011-07-364224
dc.identifier.issn00064971
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/116988
dc.description.abstractWe performed a comprehensive genomewide miRNA expression profiling of extranodal nasal-type natural killer/T-cell lymphoma (NKTL) using formalin-fixed paraffin-embedded tissue (n ∇ 30) and NK cell lines (n ∇ 6) compared with normal NK cells, with the objective of understanding the pathogenetic role of miRNA deregulation in NKTL. Compared with normal NK cells, differentially expressed miRNAs in NKTL are predominantly downregulated. Re-expression of downregulated miRNAs, such as miR-101, miR- 26a, miR26b, miR-28-5, and miR-363, reduced the growth of the NK cell line and modulated the expression of their predicted target genes, suggesting the potential functional role of the deregulated miRNAs in the oncogenesis of NKTL. Taken together, the predicted targets whose expression is inversely correlated with the expression of deregulated miRNA in NKTL are significantly enriched for genes involved in cell cycle-related, p53, and MAPK signaling pathways. We also performed immunohistochemical validation for selected target proteins and found overexpression of MUM1, BLIMP1, and STMN1 in NKTL, and notably, a corresponding increase in MYC expression. Because MYC is known to cause repression of miRNA expression, it is possible that MYC activation in NKTL may contribute to the suppression of the miRNAs regulating MUM1, BLIMP1, and STMN1. © 2011 by The American Society of Hematology.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1182/blood-2011-07-364224
dc.sourceScopus
dc.typeArticle
dc.contributor.departmentCANCER SCIENCE INSTITUTE OF SINGAPORE
dc.description.doi10.1182/blood-2011-07-364224
dc.description.sourcetitleBlood
dc.description.volume118
dc.description.issue18
dc.description.page4919-4929
dc.description.codenBLOOA
dc.identifier.isiut000296714500021
Appears in Collections:Staff Publications

Show simple item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

70
checked on Apr 7, 2021

WEB OF SCIENCETM
Citations

57
checked on Jul 10, 2019

Page view(s)

83
checked on Apr 10, 2021

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.