Please use this identifier to cite or link to this item: https://doi.org/10.1111/j.1349-7006.2010.01793.x
Title: Comparison of the pharmacokinetics and pharmacodynamics of S-1 between Caucasian and East Asian patients
Authors: Chuah, B.
Goh, B.-C.
Lee, S.-C. 
Soong, R. 
Lau, F.
Mulay, M.
Dinolfo, M.
Lim, S.-E.
Soo, R.
Furuie, T.
Saito, K.
Zergebel, C.
Rosen, L.S.
Issue Date: Feb-2011
Citation: Chuah, B., Goh, B.-C., Lee, S.-C., Soong, R., Lau, F., Mulay, M., Dinolfo, M., Lim, S.-E., Soo, R., Furuie, T., Saito, K., Zergebel, C., Rosen, L.S. (2011-02). Comparison of the pharmacokinetics and pharmacodynamics of S-1 between Caucasian and East Asian patients. Cancer Science 102 (2) : 478-483. ScholarBank@NUS Repository. https://doi.org/10.1111/j.1349-7006.2010.01793.x
Abstract: S-1 is an oral fluoropyrimidine anti-neoplastic agent that is converted by CYP2A6 to 5-fluorouracil (5FU). We prospectively studied the pharmacokinetics and pharmacodynamics of S-1 in two groups of East Asian and Caucasian patients with solid malignancy refractory to standard chemotherapy, or for which 5FU was indicated, to elucidate differences in relation to CYP2A6 genotype and phenotype. S-1 was given orally at 30mg/m2 b.i.d. for 14days every 21days. Dose normalized AUC0-48h for tegafur (P=0.05) and gimeracil (P=0.036) were higher in East Asians; conversely, AUC0-48h of fluoro-β-alanine was higher in Caucasians (P=0.044). Exposure to 5FU was similar in both groups (P=0.967). Mean cotinine:nicotine ratio was 54% higher in the Caucasian group (P=0.03), and correlated with oral clearance of tegafur (r=0.59; P=0.002). Grade 3/4 gastrointestinal toxicities were more common in Caucasians than Asians (21%vs 0%). Treatment with S-1 yields no significant difference in 5FU exposure between Caucasians and East Asians. © 2010 Japanese Cancer Association.
Source Title: Cancer Science
URI: http://scholarbank.nus.edu.sg/handle/10635/116958
ISSN: 13479032
DOI: 10.1111/j.1349-7006.2010.01793.x
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

79
checked on Jan 14, 2020

WEB OF SCIENCETM
Citations

77
checked on Jan 14, 2020

Page view(s)

91
checked on Jan 17, 2020

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.