Please use this identifier to cite or link to this item: https://doi.org/10.1002/cm.21082
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dc.titleComparing contractile apparatus-driven cytokinesis mechanisms across kingdoms
dc.contributor.authorBalasubramanian, M.K.
dc.contributor.authorSrinivasan, R.
dc.contributor.authorHuang, Y.
dc.contributor.authorNg, K.-H.
dc.date.accessioned2014-12-12T07:55:07Z
dc.date.available2014-12-12T07:55:07Z
dc.date.issued2012-11
dc.identifier.citationBalasubramanian, M.K., Srinivasan, R., Huang, Y., Ng, K.-H. (2012-11). Comparing contractile apparatus-driven cytokinesis mechanisms across kingdoms. Cytoskeleton 69 (11) : 942-956. ScholarBank@NUS Repository. https://doi.org/10.1002/cm.21082
dc.identifier.issn19493584
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/116872
dc.description.abstractCytokinesis is the final stage of the cell cycle during which a cell physically divides into two daughters through the assembly of new membranes (and cell wall in some cases) between the forming daughters. New membrane assembly can either proceed centripetally behind a contractile apparatus, as in the case of prokaryotes, archaea, fungi, and animals or expand centrifugally, as in the case of higher plants. In this article, we compare the mechanisms of cytokinesis in diverse organisms dividing through the use of a contractile apparatus. While an actomyosin ring participates in cytokinesis in almost all centripetally dividing eukaryotes, the majority of bacteria and archaea (except Crenarchaea) divide using a ring composed of the tubulin-related protein FtsZ. Curiously, despite molecular conservation of the division machinery components, division site placement and its cell cycle regulation occur by a variety of unrelated mechanisms even among organisms from the same kingdom. While molecular motors and cytoskeletal polymer dynamics contribute to force generation during eukaryotic cytokinesis, cytoskeletal polymer dynamics alone appears to be sufficient for force generation during prokaryotic cytokinesis. Intriguingly, there are life forms on this planet that appear to lack molecules currently known to participate in cytokinesis and how these cells perform cytokinesis remains a mystery waiting to be unravelled. © 2012 Wiley Periodicals, Inc.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1002/cm.21082
dc.sourceScopus
dc.subjectContractile apparatus
dc.subjectCytokinesis
dc.subjectCytoskeleton
dc.typeReview
dc.contributor.departmentMECHANOBIOLOGY INSTITUTE
dc.description.doi10.1002/cm.21082
dc.description.sourcetitleCytoskeleton
dc.description.volume69
dc.description.issue11
dc.description.page942-956
dc.identifier.isiut000313747400008
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