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|Title:||100 Breast cancer genome sequencing: Heterogeneity-based diagnostic and therapeutic perspectives||Authors:||Ku, C.-S.||Issue Date:||Jul-2012||Citation:||Ku, C.-S. (2012-07). 100 Breast cancer genome sequencing: Heterogeneity-based diagnostic and therapeutic perspectives. Gastric and Breast Cancer 11 (3) : 127-130. ScholarBank@NUS Repository. https://doi.org/10.2122/gbc.2012.0233||Abstract:||Genes and mutations involved in breast cancer vary considerable reveals a latest study published in Nature 1. Applying whole-exome sequencing in primary and metastatic tumors from 100 breast cancer patients, Stephens and colleagues 1 found 73 different combinations of cancer genes. This study reveals a wide genetic heterogeneity and nearly a specific for each patient mutational landscape. What are the consequences of this report on the clinic? How many driver mutations are required for transforming a normal cell to cancer cell? Can this WES-based testing lead to personalized therapeutics?||Source Title:||Gastric and Breast Cancer||URI:||http://scholarbank.nus.edu.sg/handle/10635/116864||ISSN:||11097655||DOI:||10.2122/gbc.2012.0233|
|Appears in Collections:||Staff Publications|
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