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https://doi.org/10.1016/S0925-4773(01)00536-6
Title: | Expression of brain subtype creatine kinase in the zebrafish embryo | Authors: | Dickmeis, T. Rastegar, S. Aanstad, P. Clark, M. Fischer, N. Plessy, C. Rosa, F. Korzh, V. Strähle, U. |
Keywords: | Embryogenesis Energy shuttle Gastrulation Limb Maternal transcript Neuronal differentiation Primary neurons Somite Zebrafish |
Issue Date: | 2001 | Citation: | Dickmeis, T., Rastegar, S., Aanstad, P., Clark, M., Fischer, N., Plessy, C., Rosa, F., Korzh, V., Strähle, U. (2001). Expression of brain subtype creatine kinase in the zebrafish embryo. Mechanisms of Development 109 (2) : 409-412. ScholarBank@NUS Repository. https://doi.org/10.1016/S0925-4773(01)00536-6 | Abstract: | Creatine kinases (CK) play crucial roles in intracellular energy transfer. We have isolated a cDNA from zebrafish embryos, which encodes a CK highly related to the mammalian brain subtype creatine kinase (BCK). The bck mRNA is expressed maternally in the zebrafish embryo and transcripts are distributed uniformly in blastula and gastrula stages. Expression becomes restricted to the prechordal plate and the nervous system during subsequent somitogenesis stages. bck transcripts are abundant in primary neurons in the developing central nervous system of the 1-day-old embryo. While some bck expression persists in the hindbrain, expression vanishes in the spinal cord of the 2-day-old embryo. In summary, the expression pattern of bck is highly dynamic and suggests a role for bck during gastrulation and neuronal differentiation. © 2001 Elsevier Science Ireland Ltd. All rights reserved. | Source Title: | Mechanisms of Development | URI: | http://scholarbank.nus.edu.sg/handle/10635/116339 | ISSN: | 09254773 | DOI: | 10.1016/S0925-4773(01)00536-6 |
Appears in Collections: | Staff Publications |
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