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Title: Clinical predictors of stent thrombosis in the "real world" drug-eluting stent era
Authors: Tin-Hay, E.L.
Poh, K.-K.
Lim, Y.-T.
Low, A.F.-H.
Lee, C.-H.
Teo, S.-G. 
Lim, J.
Lim, I.-H.
Tan, H.-C.
Keywords: Drug-eluting stent
Percutaneous coronary intervention
Stent thrombosis
Issue Date: 3-Dec-2010
Citation: Tin-Hay, E.L., Poh, K.-K., Lim, Y.-T., Low, A.F.-H., Lee, C.-H., Teo, S.-G., Lim, J., Lim, I.-H., Tan, H.-C. (2010-12-03). Clinical predictors of stent thrombosis in the "real world" drug-eluting stent era. International Journal of Cardiology 145 (3) : 422-425. ScholarBank@NUS Repository.
Abstract: Background: Drug-eluting stents (DESs) are effective in reducing restenosis and the need for repeat revascularization procedures in patients who undergo percutaneous coronary intervention (PCI). There is however an increased concern with the safety of DES with regard to stent thrombosis (ST). We examined the incidence of ST among patients who received DES and determined the clinical predictors. Methods: All patients who underwent PCI in our centre were prospectively enrolled in a cardiovascular database. All cases of ST, as defined by 2006 Academic Research Consortium (ARC) hierarchical classification as definite and probable, from August 2002 to August 2006 were reviewed and analyzed. The clinical, angiographic and procedural characteristics of patients who developed ST were compared with those who did not. Results: The study population comprised 1580 patients who received DES implantation. The cumulative incidence of ST was 1.5%: acute ST 0.2%, subacute ST 0.9%, late ST 0.2% and very late ST 0.2%. Mortality and myocardial infarction occurred in 16% and 84% of patients, respectively, as a consequence of ST. Multivariate analysis showed that patients presenting with cardiogenic shock, acute coronary syndrome, presence of multivessel disease, impaired baseline TIMI flow and higher number of stents implanted per lesion were predictive of ST. Conclusion: The incidence of DES ST in our 'real world' registry was low. There were clinical and angiographic characteristics identified as independent predictors of ST. © 2009 Elsevier Ireland Ltd.
Source Title: International Journal of Cardiology
ISSN: 01675273
DOI: 10.1016/j.ijcard.2009.05.038
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