Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.mito.2012.06.004
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dc.titleRoles of thioredoxin binding protein (TXNIP) in oxidative stress, apoptosis and cancer
dc.contributor.authorZhou, J.
dc.contributor.authorChng, W.-J.
dc.date.accessioned2014-12-12T07:37:14Z
dc.date.available2014-12-12T07:37:14Z
dc.date.issued2013-05
dc.identifier.citationZhou, J., Chng, W.-J. (2013-05). Roles of thioredoxin binding protein (TXNIP) in oxidative stress, apoptosis and cancer. Mitochondrion 13 (3) : 163-169. ScholarBank@NUS Repository. https://doi.org/10.1016/j.mito.2012.06.004
dc.identifier.issn15677249
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/116177
dc.description.abstractThioredoxin binding protein (TXNIP) has multiple functions and plays an important role in redox homeostasis. TXNIP increases the production of reactive oxygen species (ROS), and oxidative stress, resulting in cellular apoptosis. It has been identified as a tumor suppressor gene (TSG) in various solid tumors and hematological malignancies. In the present review, we will first provide an overview of TXNIP protein and function, followed by a summary of the major studies that have demonstrated the frequent repression of TXNIP in cancers. Functional characterization of TXNIP knockout mouse model is summarized. We will then discuss the use of small molecular inhibitors to reactivate TXNIP expression as a novel anticancer strategy. © 2012 Elsevier B.V. and Mitochondria Research Society.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.mito.2012.06.004
dc.sourceScopus
dc.subjectApoptosis
dc.subjectLeukemia
dc.subjectOxidative stress
dc.subjectReactive oxygen species (ROS)
dc.subjectSolid tumor
dc.subjectTXNIP/VDUP-1/TBP-2
dc.typeReview
dc.contributor.departmentCANCER SCIENCE INSTITUTE OF SINGAPORE
dc.description.doi10.1016/j.mito.2012.06.004
dc.description.sourcetitleMitochondrion
dc.description.volume13
dc.description.issue3
dc.description.page163-169
dc.description.codenMITOC
dc.identifier.isiut000317445700003
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