Please use this identifier to cite or link to this item:
|Title:||Transposon mutagenesis identifies genes driving hepatocellular carcinoma in a chronic hepatitis B mouse model||Authors:||Bard-Chapeau, E.A.
De Jong, J.
|Issue Date:||Jan-2014||Citation:||Bard-Chapeau, E.A., Nguyen, A.-T., Rust, A.G., Sayadi, A., Lee, P., Chua, B.Q., New, L.-S., De Jong, J., Ward, J.M., Chin, C.K.Y., Chew, V., Toh, H.C., Abastado, J.-P., Benoukraf, T., Soong, R., Bard, F.A., Dupuy, A.J., Johnson, R.L., Radda, G.K., Chan, E.C.Y., Wessels, L.F.A., Adams, D.J., Jenkins, N.A., Copeland, N.G. (2014-01). Transposon mutagenesis identifies genes driving hepatocellular carcinoma in a chronic hepatitis B mouse model. Nature Genetics 46 (1) : 24-32. ScholarBank@NUS Repository. https://doi.org/10.1038/ng.2847||Abstract:||The most common risk factor for developing hepatocellular carcinoma (HCC) is chronic infection with hepatitis B virus (HBV). To better understand the evolutionary forces driving HCC, we performed a near-saturating transposon mutagenesis screen in a mouse HBV model of HCC. This screen identified 21 candidate early stage drivers and a very large number (2,860) of candidate later stage drivers that were enriched for genes that are mutated, deregulated or functioning in signaling pathways important for human HCC, with a striking 1,199 genes being linked to cellular metabolic processes. Our study provides a comprehensive overview of the genetic landscape of HCC. © 2014 Nature America, Inc.||Source Title:||Nature Genetics||URI:||http://scholarbank.nus.edu.sg/handle/10635/116010||ISSN:||10614036||DOI:||10.1038/ng.2847|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Aug 21, 2019
WEB OF SCIENCETM
checked on Aug 14, 2019
checked on Aug 16, 2019
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.