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Title: Solid-phase synthesis of N-acyl-N'-carbamoylguanidines
Authors: Lin, P.
Ganesan, A. 
Keywords: Combinatorial chemistry
Solid-phase synthesis
Issue Date: 24-Dec-1998
Citation: Lin, P., Ganesan, A. (1998-12-24). Solid-phase synthesis of N-acyl-N'-carbamoylguanidines. Tetrahedron Letters 39 (52) : 9789-9792. ScholarBank@NUS Repository.
Abstract: Amino acids immobilized on polystyrene-Wang or Rink amide resin were reacted with p-nitrophenyl chloroformate to give an activated urethane that was displaced by S-methylisothiourea. Following N-acylation with an acid chloride, the thiomethyl group was displaced by primary or secondary amines with the aid of mercury (II) chloride to yield the unsymmetrically substituted title compounds after resin cleavage.
Source Title: Tetrahedron Letters
ISSN: 00404039
DOI: 10.1016/S0040-4039(98)02174-1
Appears in Collections:Staff Publications

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