Please use this identifier to cite or link to this item:
https://doi.org/10.1016/j.ccr.2013.10.003
Title: | Runx3 Inactivation Is a Crucial Early Event in the Development of Lung Adenocarcinoma | Authors: | Lee, Y.-S. Lee, J.-W. Jang, J.-W. Chi, X.-Z. Kim, J.-H. Li, Y.-H. Kim, M.-K. Kim, D.-M. Choi, B.-S. Kim, E.-G. Chung, J.-H. Lee, O.-J. Lee, Y.-M. Suh, J.-W. Chuang, L. Ito, Y. Bae, S.-C. |
Issue Date: | 11-Nov-2013 | Citation: | Lee, Y.-S., Lee, J.-W., Jang, J.-W., Chi, X.-Z., Kim, J.-H., Li, Y.-H., Kim, M.-K., Kim, D.-M., Choi, B.-S., Kim, E.-G., Chung, J.-H., Lee, O.-J., Lee, Y.-M., Suh, J.-W., Chuang, L., Ito, Y., Bae, S.-C. (2013-11-11). Runx3 Inactivation Is a Crucial Early Event in the Development of Lung Adenocarcinoma. Cancer Cell 24 (5) : 603-616. ScholarBank@NUS Repository. https://doi.org/10.1016/j.ccr.2013.10.003 | Abstract: | Targeted inactivation of Runx3 in mouse lung induced mucinous and nonmucinous adenomas and markedly shortened latency of adenocarcinoma formation induced by oncogenic K-Ras. RUNX3 was frequently inactivated in K-RAS mutated human lung adenocarcinomas. A functional genetic screen of a fly mutant library and molecular analysis in cultured cell lines revealed that Runx3 forms a complex with BRD2 in a K-Ras-dependent manner in the early phase of the cell cycle; this complex induces expression of p14ARF/p19Arf and p21WAF/CIP. When K-Ras was constitutively activated, the Runx3-BRD2 complex was stably maintained and expression of both p14ARF and p21WAF/CIP was prolonged. These results provide a missing link between oncogenic K-Ras and the p14ARF-p53 pathway, and may explain how cells defend against oncogenic K-Ras. © 2013 Elsevier Inc. | Source Title: | Cancer Cell | URI: | http://scholarbank.nus.edu.sg/handle/10635/115922 | ISSN: | 15356108 | DOI: | 10.1016/j.ccr.2013.10.003 |
Appears in Collections: | Staff Publications |
Show full item record
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.