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Title: Pak functions downstream of Dock to regulate photoreceptor axon guidance in Drosophila
Authors: Hing, H.
Xiao, J.
Harden, N. 
Lim, L.
Lawrence Zipursky, S.
Issue Date: 25-Jun-1999
Citation: Hing, H., Xiao, J., Harden, N., Lim, L., Lawrence Zipursky, S. (1999-06-25). Pak functions downstream of Dock to regulate photoreceptor axon guidance in Drosophila. Cell 97 (7) : 853-863. ScholarBank@NUS Repository.
Abstract: The SH2/SH3 adaptor protein Dock has been proposed to transduce signals from guidance receptors to the actin cytoskeleton in Drosophila photoreceptor (R cell) growth cones. Here, we demonstrate that Drosophila p21-activated kinase (Pak) is required in a Dock pathway regulating R cell axon guidance and targeting. Dock and Pak colocalize to R cell axons and growth cones, physically interact, and their loss-of-function phenotypes are indistinguishable. Normal patterns of R cell connectivity require Pak's kinase activity and binding sites for both Dock and Cdc42/Rac. A membrane- tethered form of Pak (Pak(myr)) acts as a dominant gain-of-function protein. Retinal expression of Pak(myr) rescues the R cell connectivity phenotype in dock mutants. These data establish Pak as a critical regulator of axon guidance and a downstream effector of Dock in vivo.
Source Title: Cell
ISSN: 00928674
DOI: 10.1016/S0092-8674(00)80798-9
Appears in Collections:Staff Publications

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