Please use this identifier to cite or link to this item:
https://doi.org/10.1016/S0014-5793(01)02409-7
DC Field | Value | |
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dc.title | An integrated approach in the discovery and characterization of a novel nuclear protein over-expressed in liver and pancreatic tumors | |
dc.contributor.author | Choong, M.L. | |
dc.contributor.author | Tan, L.K. | |
dc.contributor.author | Lo, S.L. | |
dc.contributor.author | Ren, E.-C. | |
dc.contributor.author | Ou, K. | |
dc.contributor.author | Ong, S.-E. | |
dc.contributor.author | Liang, R.C.M.Y. | |
dc.contributor.author | Seow, T.K. | |
dc.contributor.author | Chung, M.C.M. | |
dc.date.accessioned | 2014-12-12T07:29:41Z | |
dc.date.available | 2014-12-12T07:29:41Z | |
dc.date.issued | 2001-05-11 | |
dc.identifier.citation | Choong, M.L., Tan, L.K., Lo, S.L., Ren, E.-C., Ou, K., Ong, S.-E., Liang, R.C.M.Y., Seow, T.K., Chung, M.C.M. (2001-05-11). An integrated approach in the discovery and characterization of a novel nuclear protein over-expressed in liver and pancreatic tumors. FEBS Letters 496 (2-3) : 109-116. ScholarBank@NUS Repository. https://doi.org/10.1016/S0014-5793(01)02409-7 | |
dc.identifier.issn | 00145793 | |
dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/115583 | |
dc.description.abstract | An integrated approach in protein discovery through the use of multidisciplinary tools was reported. A novel protein, Hcc-1, was identified by analysis of the hepatocellular carcinoma (HCC)-M cell proteome. The assembled EST sequence of the 210 amino acid novel protein was subsequently confirmed by rapid amplification of cDNA ends (RACE). A total of 687 bp at the 5′ untranslated region of Hcc-1 was identified. Promoter activity and several upstream open reading frames (uORFs) were demonstrated at this region. Bioinformatics prediction showed that the first 42 amino acids of the protein is a SAP domain with sequence matches to hnRNP from various vertebrate species. The Hcc-1 protein was localized to the cell nucleus while the gene was localized to chromosome 7q22.1. Hcc-1 cDNA level was increased in pancreatic adenocarcinoma. The level was also increased in well-differentiated hepatocellular carcinoma but decreases as the carcinoma progressed to a poorly differentiated stage. © 2001 Published by Elsevier Science B.V. | |
dc.description.uri | http://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/S0014-5793(01)02409-7 | |
dc.source | Scopus | |
dc.subject | HCC-M | |
dc.subject | Intronless gene | |
dc.subject | Nuclear protein | |
dc.subject | Upstream open reading frame | |
dc.type | Article | |
dc.contributor.department | BIOPROCESSING TECHNOLOGY CENTRE | |
dc.description.doi | 10.1016/S0014-5793(01)02409-7 | |
dc.description.sourcetitle | FEBS Letters | |
dc.description.volume | 496 | |
dc.description.issue | 2-3 | |
dc.description.page | 109-116 | |
dc.description.coden | FEBLA | |
dc.identifier.isiut | 000168796700009 | |
Appears in Collections: | Staff Publications |
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