Please use this identifier to cite or link to this item: https://doi.org/10.1083/jcb.200501126
DC FieldValue
dc.titleA positive feedback loop between dumbfounded and rolling pebbles leads to myotube enlargement in Drosophila
dc.contributor.authorMenon, S.D.
dc.contributor.authorOsman, Z.
dc.contributor.authorChenchill, K.
dc.contributor.authorChia, W.
dc.date.accessioned2014-12-12T07:29:30Z
dc.date.available2014-12-12T07:29:30Z
dc.date.issued2005-06
dc.identifier.citationMenon, S.D., Osman, Z., Chenchill, K., Chia, W. (2005-06). A positive feedback loop between dumbfounded and rolling pebbles leads to myotube enlargement in Drosophila. Journal of Cell Biology 169 (6) : 909-920. ScholarBank@NUS Repository. https://doi.org/10.1083/jcb.200501126
dc.identifier.issn00219525
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/115567
dc.description.abstractIn Drosophila, myoblasts are subdivided into founders and fusion-competent myoblasts (fcm) with myotubes forming through fusion of one founder and several fcm. Duf and rolling pebbles 7 (Rols7; also known as antisocial) are expressed in founders, whereas sticks and stones (SNS) is present in fcm. Duf attracts fcm toward founders and also causes translocation of Rols7 from the cytoplasm to the fusion site. We show that Duf is a type 1 transmembrane protein that induces Rols7 translocation specifically when present intact and engaged in homophilic or Duf-SNS adhesion. Although its membrane-anchored extracellular domain functions as an attractant and is sufficient for the initial round of fusion, subsequent fusions require replenishment of Duf through cotranslocation with Rols7 tetratricopeptide repeat/coiled-coil domain-containing vesicles to the founder/myotube surface, causing both Duf and Rols7 to be at fusion sites between founders/myotubes and fcm. This implicates the Duf-Rols7 positive feedback loop to the occurrence of fusion at specific sites along the membrane and provides a mechanism by which the rate of fusion is controlled. © The Rockefeller University Press.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1083/jcb.200501126
dc.sourceScopus
dc.typeArticle
dc.contributor.departmentINSTITUTE OF MOLECULAR & CELL BIOLOGY
dc.contributor.departmentDEAN'S OFFICE (MEDICINE)
dc.description.doi10.1083/jcb.200501126
dc.description.sourcetitleJournal of Cell Biology
dc.description.volume169
dc.description.issue6
dc.description.page909-920
dc.description.codenJCLBA
dc.identifier.isiut000229930300008
Appears in Collections:Staff Publications

Show simple item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

57
checked on Dec 7, 2022

WEB OF SCIENCETM
Citations

54
checked on Nov 30, 2022

Page view(s)

159
checked on Nov 24, 2022

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.