Please use this identifier to cite or link to this item: https://doi.org/10.3109/10408444.2012.698405
DC FieldValue
dc.titleSulfur mustard and respiratory diseases
dc.contributor.authorTang, F.R.
dc.contributor.authorLoke, W.K.
dc.date.accessioned2014-12-12T07:16:55Z
dc.date.available2014-12-12T07:16:55Z
dc.date.issued2012-09
dc.identifier.citationTang, F.R., Loke, W.K. (2012-09). Sulfur mustard and respiratory diseases. Critical Reviews in Toxicology 42 (8) : 688-702. ScholarBank@NUS Repository. https://doi.org/10.3109/10408444.2012.698405
dc.identifier.issn10408444
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/115548
dc.description.abstractVictims exposed to sulfur mustard (HD) in World War I and IranIraq war, and those suffered occupational or accidental exposure have endured discomfort in the respiratory system at early stages after exposure, and marked general physical deterioration at late stages due to pulmonary fibrosis, bronchiolitis obliterans or lung cancer. At molecule levels, significant changes of cytokines and chemokines in bronchoalveolar lavage and serum, and of selectins (in particular sE-selectin) and soluble Fas ligand in the serum have been reported in recent studies of patients exposed to HD in IranIraq war, suggesting that these molecules may be associated with the pathophysiological development of pulmonary diseases. Experimental studies in rodents have revealed that reactive oxygen and nitrogen species, their product peroxynitrite (ONOO-), nitric oxide synthase, glutathione, poly (adenosine diphosphate-ribose) polymerase, activating protein-1 signaling pathway are promising drug targets for preventing HD-induced toxicity, whereas N-acetyl cysteine, tocopherols, melatonin, aprotinin and many other molecules have been proved to be effective in prevention of HD-induced damage to the respiratory system in different animal models. In this paper, we will systemically review clinical and pathophysiological changes of respiratory system in victims exposed to HD in the last century, update clinicians and researchers on the mechanism of HD-induced acute and chronic lung damages, and on the relevant drug targets for future development of antidotes for HD. Further research directions will also be proposed. © 2012 Informa Healthcare USA, Inc.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.3109/10408444.2012.698405
dc.sourceScopus
dc.subjectDrug targets
dc.subjectIranIraq war
dc.subjectMolecular mechanism
dc.subjectPulmonary diseases
dc.subjectSulfur mustard
dc.subjectWorld War I
dc.typeReview
dc.contributor.departmentTEMASEK LABORATORIES
dc.description.doi10.3109/10408444.2012.698405
dc.description.sourcetitleCritical Reviews in Toxicology
dc.description.volume42
dc.description.issue8
dc.description.page688-702
dc.description.codenCRTXB
dc.identifier.isiut000307995000004
Appears in Collections:Staff Publications

Show simple item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

41
checked on Apr 12, 2021

WEB OF SCIENCETM
Citations

35
checked on Apr 12, 2021

Page view(s)

79
checked on Apr 10, 2021

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.