Please use this identifier to cite or link to this item: https://doi.org/10.1515/CCLM.2011.715
DC FieldValue
dc.titleRecent progress and clinical importance on pharmacogenetics in cancer therapy
dc.contributor.authorSoh, T.I.P.
dc.contributor.authorYong, W.P.
dc.contributor.authorInnocenti, F.
dc.date.accessioned2014-12-12T07:16:54Z
dc.date.available2014-12-12T07:16:54Z
dc.date.issued2011-10-01
dc.identifier.citationSoh, T.I.P., Yong, W.P., Innocenti, F. (2011-10-01). Recent progress and clinical importance on pharmacogenetics in cancer therapy. Clinical Chemistry and Laboratory Medicine 49 (10) : 1621-1632. ScholarBank@NUS Repository. https://doi.org/10.1515/CCLM.2011.715
dc.identifier.issn14346621
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/115547
dc.description.abstractRecent advances have provided unprecedented opportunities to identify prognostic and predictive markers of efficacy of cancer therapy. Genetic markers can be used to exclude patients who will not benefit from therapy, exclude patients at high risk of severe toxicity and adjust dosing. Genomic approaches for marker discovery now include genome-wide association studies and tumor DNA sequencing. The challenge is now to select markers for which there is enough evidence to transition them to the clinic. The hurdles include the inherent low frequency of many of these markers, the lengthy validation process through trials, as well as legislative and economic hurdles. Attempts to answer questions about certain markers more quickly have led to an increased popularity of trials with enrichment design, especially in light of the dramatic phase I results seen in recent months. Personalized medicine in oncology is a step closer to reality. © 2011 by Walter de Gruyter Berlin Boston.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1515/CCLM.2011.715
dc.sourceScopus
dc.subjectbiomarkers
dc.subjectcancer therapy
dc.subjectpharmacogenetics
dc.typeReview
dc.contributor.departmentCANCER SCIENCE INSTITUTE OF SINGAPORE
dc.description.doi10.1515/CCLM.2011.715
dc.description.sourcetitleClinical Chemistry and Laboratory Medicine
dc.description.volume49
dc.description.issue10
dc.description.page1621-1632
dc.description.codenCCLMF
dc.identifier.isiut000296591500005
Appears in Collections:Staff Publications

Show simple item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

12
checked on Jul 19, 2019

WEB OF SCIENCETM
Citations

14
checked on Jul 19, 2019

Page view(s)

33
checked on Jul 19, 2019

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.