Please use this identifier to cite or link to this item: https://doi.org/10.1038/nn.2794
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dc.titleSFRPs act as negative modulators of ADAM10 to regulate retinal neurogenesis
dc.contributor.authorEsteve, P.
dc.contributor.authorSandonà S, A.
dc.contributor.authorCardozo, M.
dc.contributor.authorMalapeira, J.
dc.contributor.authorIbañez, C.
dc.contributor.authorCrespo, I.
dc.contributor.authorMarcos, S.
dc.contributor.authorGonzalez-Garcia, S.
dc.contributor.authorToribio, M.L.
dc.contributor.authorArribas, J.
dc.contributor.authorShimono, A.
dc.contributor.authorGuerrero, I.
dc.contributor.authorBovolenta, P.
dc.date.accessioned2014-12-12T07:13:31Z
dc.date.available2014-12-12T07:13:31Z
dc.date.issued2011-05
dc.identifier.citationEsteve, P., Sandonà S, A., Cardozo, M., Malapeira, J., Ibañez, C., Crespo, I., Marcos, S., Gonzalez-Garcia, S., Toribio, M.L., Arribas, J., Shimono, A., Guerrero, I., Bovolenta, P. (2011-05). SFRPs act as negative modulators of ADAM10 to regulate retinal neurogenesis. Nature Neuroscience 14 (5) : 562-570. ScholarBank@NUS Repository. https://doi.org/10.1038/nn.2794
dc.identifier.issn10976256
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/115284
dc.description.abstractIt is well established that retinal neurogenesis in mouse embryos requires the activation of Notch signaling, but is independent of the Wnt signaling pathway. We found that genetic inactivation of Sfrp1 and Sfrp2, two postulated Wnt antagonists, perturbs retinal neurogenesis. In retinas from Sfrp1 -/-; Sfrp2 -/- embryos, Notch signaling was transiently upregulated because Sfrps bind ADAM10 metalloprotease and downregulate its activity, an important step in Notch activation. The proteolysis of other ADAM10 substrates, including APP, was consistently altered in Sfrp mutants, whereas pharmacological inhibition of ADAM10 partially rescued the Sfrp1 -/-; Sfrp2 -/- retinal phenotype. Conversely, ectopic Sfrp1 expression in the Drosophila wing imaginal disc prevented the expression of Notch targets, and this was restored by the coexpression of Kuzbanian, the Drosophila ADAM10 homolog. Together, these data indicate that Sfrps inhibit the ADAM10 metalloprotease, which might have important implications in pathological events, including cancer and Alzheimer's disease. © 2011 Nature America, Inc. All rights reserved.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1038/nn.2794
dc.sourceScopus
dc.typeArticle
dc.contributor.departmentCANCER SCIENCE INSTITUTE OF SINGAPORE
dc.description.doi10.1038/nn.2794
dc.description.sourcetitleNature Neuroscience
dc.description.volume14
dc.description.issue5
dc.description.page562-570
dc.description.codenNANEF
dc.identifier.isiut000289886600011
Appears in Collections:Staff Publications

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