Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.ejca.2008.02.007
Title: MDM2 SNP309 G allele decreases risk but does not affect onset age or survival of Chinese leukaemia patients
Authors: Phang, B.H.
Linn, Y.C.
Li, H.
Sabapathy, K. 
Keywords: Leukaemia
MDM2 SNP
p53 codon 72 SNP
Survival
Issue Date: Mar-2008
Citation: Phang, B.H., Linn, Y.C., Li, H., Sabapathy, K. (2008-03). MDM2 SNP309 G allele decreases risk but does not affect onset age or survival of Chinese leukaemia patients. European Journal of Cancer 44 (5) : 760-766. ScholarBank@NUS Repository. https://doi.org/10.1016/j.ejca.2008.02.007
Abstract: Although mutations in p53 are rare in leukaemia, MDM2, the negative regulator of p53, is often overexpressed. Recently, a single nucleotide polymorphism (SNP) in the MDM2 promoter - within the oestrogen-receptor-binding region - resulting in either a G or T allele was shown to affect its transcription, with elevated MDM2 being produced when it is a G allele. Expectedly, SNP309G females were found to be at a higher risk of accelerated onset of cancers. We have therefore analysed, in a pilot study, whether the status of MDM2 SNP309 and p53 codon-72 polymorphism, which was also shown to affect cancer predisposition, would affect cancer risk, onset age, overall survival and response to therapy in Chinese leukaemia patients. p53 SNP was not associated with any of the parameters. However, in contrast to expectations, the MDM2 SNP309G allele was associated with reduced risk of leukaemia. No other association was found between SNP309 and other parameters in both males and females. Thus, the data highlights ethnic differences in the effects of this SNP on cancer risk. © 2008 Elsevier Ltd. All rights reserved.
Source Title: European Journal of Cancer
URI: http://scholarbank.nus.edu.sg/handle/10635/115182
ISSN: 09598049
DOI: 10.1016/j.ejca.2008.02.007
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

34
checked on Jan 27, 2023

WEB OF SCIENCETM
Citations

33
checked on Jan 18, 2023

Page view(s)

168
checked on Jan 26, 2023

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.