Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/114930
Title: Comparison of the measurement properties between a short and generic instrument, the 5-level EuroQoL Group's 5-dimension (EQ-5D-5L) questionnaire, and a longer and disease-specific instrument, the Functional Assessment of Cancer Therapy - Breast (FACT-B), in Asian breast cancer patients
Authors: Lee, C.F.
Luo, N. 
Ng, R.
Wong, N.S.
Yap, Y.S.
Lo, S.K.
Chia, W.K.
Yee, A.
Krishna, L.
Wong, C.
Goh, C.
Cheung, Y.B. 
Keywords: Breast cancer
Discriminative ability
EQ-5D-5L
FACT-B
Measurement properties
Non-inferiority
Issue Date: Sep-2013
Citation: Lee, C.F., Luo, N., Ng, R., Wong, N.S., Yap, Y.S., Lo, S.K., Chia, W.K., Yee, A., Krishna, L., Wong, C., Goh, C., Cheung, Y.B. (2013-09). Comparison of the measurement properties between a short and generic instrument, the 5-level EuroQoL Group's 5-dimension (EQ-5D-5L) questionnaire, and a longer and disease-specific instrument, the Functional Assessment of Cancer Therapy - Breast (FACT-B), in Asian breast cancer patients. Quality of Life Research 22 (7) : 1745-1751. ScholarBank@NUS Repository.
Abstract: Purpose: To compare the measurement precision and related properties between the 5-level EuroQoL Group's 5-dimension (EQ-5D-5L) questionnaire and the Functional Assessment of Cancer Therapy - Breast (FACT-B) questionnaire in assessing breast cancer patients. Methods: An observational study of 269 Singaporean breast cancer patients. To compare discriminative ability and responsiveness, the effect sizes (in standard deviation) of the EQ-5D-5L and the FACT-B in relation to health indicators and the change in performance status or quality of life were estimated. Test-retest reliability was examined using the intraclass correlation (ICC). Results: Using performance status, evidence of disease, and treatment status as the criteria, the differences (FACT-B minus EQ-5D-5L) in the effect size for discriminative ability were negative or closed to zero, and the 90 % confidence intervals totally fell within the zone that indicated the non-inferiority of the EQ-5D-5L. For responsiveness and test-retest reliability, the confidence intervals of the differences in effect size and ICC overlapped the non-inferiority margin; thus, non-inferiority in these two aspects could neither be confirmed nor rejected. Conclusions: The EQ-5D-5L was non-inferior to the FACT-B in discriminating breast cancer patients with different health conditions cross-sectionally. The EQ-5D-5L serves as a reasonable alternative or supplementary instrument to the FACT-B in assessing breast cancer patients' health outcomes. © 2012 Springer Science+Business Media Dordrecht.
Source Title: Quality of Life Research
URI: http://scholarbank.nus.edu.sg/handle/10635/114930
ISSN: 09629343
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