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Title: Near-infrared Raman spectroscopy for colonic cancer diagnosis
Authors: Huang, Z. 
Zheng, W. 
Colin, S. 
Keywords: Adenocarcinoma
Colon cancer
Near-infrared Raman spectroscopy
Optical diagnosis
Issue Date: 2005
Citation: Huang, Z.,Zheng, W.,Colin, S. (2005). Near-infrared Raman spectroscopy for colonic cancer diagnosis. Progress in Biomedical Optics and Imaging - Proceedings of SPIE 5862 : 4-. ScholarBank@NUS Repository.
Abstract: This study evaluated the diagnostic ability of near-infrared (NIR) Raman spectroscopy for identifying the malignant tumors from normal and benign tissues in the colon. In this work, a rapid NIR Raman system was utilized for tissue Raman studies. A total of 105 colonie specimens were used for Raman studies, including 41 normals, 18 polyps (benign), and 46 malignant tumors (22 of moderately differentiated adenocarcinomas and 24 of poorly differentiated adenocarcinomas). The results showed that high-quality Raman spectra in the 800-1800 cm-1 range can be acquired from human colonie tissues in vitro, and Raman spectra differed significantly between normal and malignant tumor tissue. The diagnostic algorithm using the Raman intensity ratios of I1085/1445 vs. I1002/1445 can yield a diagnostic sensitivity of 100%and specificity of 96.6% for differentiation between between normal, benign and malignant colonic tissue. This work demonstrates that NIR Raman spectroscopy technique has a significant potential for the noninvasive diagnosis of colon cancer in vivo based on the evaluation of changes of molecular vibrations of biomolecules in tissue. © 2005 SPIE-OSA.
Source Title: Progress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN: 16057422
Appears in Collections:Staff Publications

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