Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.semcdb.2005.02.005
Title: When timing is everything: Role of cell cycle regulation in asymmetric division
Authors: Prokopenko, S.N.
Chia, W. 
Keywords: Cell fate determination
Cyclin-dependent kinase
Drosophila
Neuroblast
Sensory organ precursor
Issue Date: Jun-2005
Citation: Prokopenko, S.N., Chia, W. (2005-06). When timing is everything: Role of cell cycle regulation in asymmetric division. Seminars in Cell and Developmental Biology 16 (3) : 423-437. ScholarBank@NUS Repository. https://doi.org/10.1016/j.semcdb.2005.02.005
Abstract: Asymmetric division is a fundamental mechanism of generating cell diversity during development. One of its hallmarks is asymmetric localization during mitosis of proteins that specify daughter cell fate. Studies in Drosophila show that subcellular localization of many proteins required for asymmetric division of neuronal progenitors correlates with progression through mitosis. Yet, how cell cycle and asymmetric division machineries cooperate remains unclear. Recent data show that (1) key cell cycle regulators are required for asymmetric localization of cell fate determinants and for cell fate determination and (2) molecules that mediate asymmetric division can also act to modulate proliferation potential of progenitor cells. © 2005 Elsevier Ltd. All rights reserved.
Source Title: Seminars in Cell and Developmental Biology
URI: http://scholarbank.nus.edu.sg/handle/10635/113825
ISSN: 10849521
DOI: 10.1016/j.semcdb.2005.02.005
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