Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.mrfmmm.2005.06.004
Title: Effect of glutathione-S-transferase polymorphisms on the cancer preventive potential of isothiocyanates: An epidemiological perspective
Authors: Seow, A. 
Vainio, H.
Yu, M.C.
Keywords: Cruciferous vegetables
Gene-diet interaction
Genetic polymorphisms
Phase II metabolizing enzymes
Issue Date: 30-Dec-2005
Citation: Seow, A., Vainio, H., Yu, M.C. (2005-12-30). Effect of glutathione-S-transferase polymorphisms on the cancer preventive potential of isothiocyanates: An epidemiological perspective. Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis 592 (1-2) : 58-67. ScholarBank@NUS Repository. https://doi.org/10.1016/j.mrfmmm.2005.06.004
Abstract: Isothiocyanates (ITCs) are widely distributed in cruciferous vegetables and are biologically active against chemical carcinogenesis due to their ability to induce phase II conjugating enzymes. Among these is the glutathione-S- transferase (GST) family of enzymes, which in turn catalyzes the metabolism of ITCs, for which it has high substrate specificity. A recent body of epidemiologic data on the inverse association between cruciferous vegetable/ITC intake and cancers of the colo-rectum, lung and breast, also support that this protective effect is greater among individuals who possess the GSTM1 or T1 null genotype, and who would be expected to accumulate higher levels of ITC at the target tissue level, a pre-requisite for their enzyme-inducing effects. The association between ITC and cancer, and its modification by GST status, is most consistent for lung cancer and appears to be strongest among current smokers. Within limits, a comparison between groups which have been stratified by GST genotype may be less susceptible to confounding by other variables, given the random assortment of genes in gametogenesis. While a more complete understanding of the overall effects on health will need to take into account other components such as indoles and anti-oxidants, the interaction between ITC intake and GST genotype may provide a firmer basis to support a biologically significant role for ITC in cruciferous vegetables. © 2005 Elsevier B.V. All rights reserved.
Source Title: Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
URI: http://scholarbank.nus.edu.sg/handle/10635/113725
ISSN: 00275107
DOI: 10.1016/j.mrfmmm.2005.06.004
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