Please use this identifier to cite or link to this item: https://doi.org/10.1007/s00439-002-0779-2
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dc.titleThymidylate synthase: A novel genetic determinant of plasma homocysteine and folate levels
dc.contributor.authorTrinh, B.N.
dc.contributor.authorOng, C.-N.
dc.contributor.authorCoetzee, G.A.
dc.contributor.authorYu, M.C.
dc.contributor.authorLaird, P.W.
dc.date.accessioned2014-12-01T06:57:21Z
dc.date.available2014-12-01T06:57:21Z
dc.date.issued2002-09
dc.identifier.citationTrinh, B.N., Ong, C.-N., Coetzee, G.A., Yu, M.C., Laird, P.W. (2002-09). Thymidylate synthase: A novel genetic determinant of plasma homocysteine and folate levels. Human Genetics 111 (3) : 299-302. ScholarBank@NUS Repository. https://doi.org/10.1007/s00439-002-0779-2
dc.identifier.issn03406717
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/113692
dc.description.abstractThe thymidylate synthase gene (TYMS or TS) encodes a tightly regulated enzyme that catalyzes the conversion of deoxyuridylate to thymidylate, and contains a tandem repeat polymorphism that affects expression of the enzyme. We have investigated the relationship between TYMS genotype and plasma concentrations of homocysteine and folate in a cohort of 505 Chinese from Singapore. TYMS 3/3 genotype was associated with reduced plasma folate and, among individuals with low dietary folate intake, with elevated plasma homocysteine levels. These associations were independent of the well-established methylenetetrahydrofolate reductase (MTHFR) C677T genotype effects on plasma folate and homocysteine levels. Our results suggest that TYMS and MTHFR complete for limiting supplies of folate required for the remethylation of homocysteine. These genetic determinants of plasma folate and homocysteine levels may be useful in identifying individuals at increased risk for cardiovascular disease. © Springer-Verlag 2002.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1007/s00439-002-0779-2
dc.sourceScopus
dc.typeArticle
dc.contributor.departmentCOMMUNITY,OCCUPATIONAL & FAMILY MEDICINE
dc.description.doi10.1007/s00439-002-0779-2
dc.description.sourcetitleHuman Genetics
dc.description.volume111
dc.description.issue3
dc.description.page299-302
dc.description.codenHUGED
dc.identifier.isiut000178488600012
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