Please use this identifier to cite or link to this item: https://doi.org/10.1111/j.1471-4159.2004.02617.x
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dc.titleThe novel neuromodulator hydrogen sulfide: An endogenous peroxynitrite 'scavenger'?
dc.contributor.authorWhiteman, M.
dc.contributor.authorArmstrong, J.S.
dc.contributor.authorChu, S.H.
dc.contributor.authorJia-Ling, S.
dc.contributor.authorWong, B.-S.
dc.contributor.authorCheung, N.S.
dc.contributor.authorHalliwell, B.
dc.contributor.authorMoore, P.K.
dc.date.accessioned2014-12-01T06:57:14Z
dc.date.available2014-12-01T06:57:14Z
dc.date.issued2004-08
dc.identifier.citationWhiteman, M., Armstrong, J.S., Chu, S.H., Jia-Ling, S., Wong, B.-S., Cheung, N.S., Halliwell, B., Moore, P.K. (2004-08). The novel neuromodulator hydrogen sulfide: An endogenous peroxynitrite 'scavenger'?. Journal of Neurochemistry 90 (3) : 765-768. ScholarBank@NUS Repository. https://doi.org/10.1111/j.1471-4159.2004.02617.x
dc.identifier.issn00223042
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/113681
dc.description.abstractHydrogen sulfide (H2S) is a well-known cytotoxic gas. Recently it has been shown to stimulate N-methyl-D-aspartate (NMDA) receptors to enhance long-term potentiation suggesting a novel neuromodulatory role in vivo. Endogenous levels of H2S in the brain are reported to range between 10 and 160 μM. Considerably lower H2S levels are reported in the brains of Alzheimer's disease (AD) patients, where levels of brain protein nitration (probably mediated by peroxynitrite) are markedly increased. Activation of NMDA receptors leads to intracellular tyrosine nitration by peroxynitrite. Because H2S and peroxynitrite are important mediators in brain function and disease, we investigated the effects of the H2S 'donor', sodium hydrogen sulfide (NaSH) on peroxynitrite-mediated damage to biomolecules and to cultured human SH-SY5Y cells. H2S significantly inhibited peroxynitrite-mediated tyrosine nitration and inactivation of α1-antiproteinase to a similar extent to reduced glutathione at each concentration tested (30-250 μM). H2S also inhibited peroxynitrite-induced cytotoxicity, intracellular protein nitration and protein oxidation in human neuroblastoma SH-SY5Y cells. These data suggest that H 2S has the potential to act as an inhibitor of peroxynitrite-mediated processes in vivo and that the potential antioxidant action of H2S deserves further study, given that extracellular GSH levels in the brain are very low.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1111/j.1471-4159.2004.02617.x
dc.sourceScopus
dc.subject3-nitrotyrosine
dc.subjectHydrogen sulfide
dc.subjectNeurodegeneration
dc.subjectNitrosative stress
dc.subjectOxidative stress
dc.subjectPeroxynitrite
dc.typeArticle
dc.contributor.departmentNATIONAL UNIVERSITY MEDICAL INSTITUTES
dc.description.doi10.1111/j.1471-4159.2004.02617.x
dc.description.sourcetitleJournal of Neurochemistry
dc.description.volume90
dc.description.issue3
dc.description.page765-768
dc.description.codenJONRA
dc.identifier.isiut000222720500028
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