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Title: The fatty acid-binding protein-2 A54T polymorphism is associated with renal disease in patients with type 2 diabetes
Authors: Canani, L.H.
Capp, C.
Ng, D.P.K. 
Choo, S.G.L.
Maia, A.L.
Nabinger, G.B.
Santos, K.
Crispim, D.
Roisemberg, I.
Krolewski, A.S.
Gross, J.L.
Issue Date: Nov-2005
Citation: Canani, L.H., Capp, C., Ng, D.P.K., Choo, S.G.L., Maia, A.L., Nabinger, G.B., Santos, K., Crispim, D., Roisemberg, I., Krolewski, A.S., Gross, J.L. (2005-11). The fatty acid-binding protein-2 A54T polymorphism is associated with renal disease in patients with type 2 diabetes. Diabetes 54 (11) : 3326-3330. ScholarBank@NUS Repository.
Abstract: The intestinal fatty-acid binding protein-2 (FABP2) gene codes a protein responsible for the absorption of long-chain fatty acids. To test whether FABP2 is a candidate gene for renal disease in patients with type 2 diabetes, a functional A54T polymorphism was genotyped in 1,042 Brazilians with type 2 diabetes. Patients were classified as having normoalbuminuria (urinary albumin excretion [UAE] >20 μg/min; n = 529), microalbuminuria (UAE 20-199 μg/min; n = 217), or proteinuria (UAE >199 μg/min; n = 160). Patients with end-stage renal disease (ESRD) (n = 136) were also included. The prevalence of the TT genotype was higher in patients with renal involvement compared with those with normoalbuminuria (odds ratio [95% CI] 2.4 [1.1-5.4]) following adjustment for type 2 diabetes duration, BMI, hypertension, A1C, and cholesterol levels. The risk was similar considering different stages of renal involvement. In a second independent patient sample (483 type 2 diabetic Caucasians residing in Massachusetts), a significant association was also observed between the TT genotype and proteinuria or ESRD (2.7 [1.0 -7.3]; P = 0.048). This study thus provides evidence that FABP2 confers susceptibility to renal disease in type 2 diabetic patients. © 2005 by the American Diabetes Association.
Source Title: Diabetes
ISSN: 00121797
DOI: 10.2337/diabetes.54.11.3326
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