Please use this identifier to cite or link to this item: https://doi.org/10.2337/diabetes.54.11.3326
Title: The fatty acid-binding protein-2 A54T polymorphism is associated with renal disease in patients with type 2 diabetes
Authors: Canani, L.H.
Capp, C.
Ng, D.P.K. 
Choo, S.G.L.
Maia, A.L.
Nabinger, G.B.
Santos, K.
Crispim, D.
Roisemberg, I.
Krolewski, A.S.
Gross, J.L.
Issue Date: Nov-2005
Citation: Canani, L.H., Capp, C., Ng, D.P.K., Choo, S.G.L., Maia, A.L., Nabinger, G.B., Santos, K., Crispim, D., Roisemberg, I., Krolewski, A.S., Gross, J.L. (2005-11). The fatty acid-binding protein-2 A54T polymorphism is associated with renal disease in patients with type 2 diabetes. Diabetes 54 (11) : 3326-3330. ScholarBank@NUS Repository. https://doi.org/10.2337/diabetes.54.11.3326
Abstract: The intestinal fatty-acid binding protein-2 (FABP2) gene codes a protein responsible for the absorption of long-chain fatty acids. To test whether FABP2 is a candidate gene for renal disease in patients with type 2 diabetes, a functional A54T polymorphism was genotyped in 1,042 Brazilians with type 2 diabetes. Patients were classified as having normoalbuminuria (urinary albumin excretion [UAE] >20 μg/min; n = 529), microalbuminuria (UAE 20-199 μg/min; n = 217), or proteinuria (UAE >199 μg/min; n = 160). Patients with end-stage renal disease (ESRD) (n = 136) were also included. The prevalence of the TT genotype was higher in patients with renal involvement compared with those with normoalbuminuria (odds ratio [95% CI] 2.4 [1.1-5.4]) following adjustment for type 2 diabetes duration, BMI, hypertension, A1C, and cholesterol levels. The risk was similar considering different stages of renal involvement. In a second independent patient sample (483 type 2 diabetic Caucasians residing in Massachusetts), a significant association was also observed between the TT genotype and proteinuria or ESRD (2.7 [1.0 -7.3]; P = 0.048). This study thus provides evidence that FABP2 confers susceptibility to renal disease in type 2 diabetic patients. © 2005 by the American Diabetes Association.
Source Title: Diabetes
URI: http://scholarbank.nus.edu.sg/handle/10635/113678
ISSN: 00121797
DOI: 10.2337/diabetes.54.11.3326
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

36
checked on Nov 23, 2022

WEB OF SCIENCETM
Citations

34
checked on Nov 23, 2022

Page view(s)

185
checked on Nov 24, 2022

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.