Please use this identifier to cite or link to this item: https://doi.org/10.1016/S1383-5718(02)00274-7
Title: The associations among semen quality, oxidative DNA damage in human spermatozoa and concentrations of cadmium, lead and selenium in seminal plasma
Authors: Xu, D.-X.
Shen, H.-M. 
Zhu, Q.-X.
Chua, L.
Wang, Q.-N.
Chia, S.-E. 
Ong, C.-N. 
Keywords: 8-Hydroxy-2′-deoxyguanosine
Cadmium
DNA damage
Lead
Selenium
Spermatozoa
Issue Date: 10-Jan-2003
Citation: Xu, D.-X., Shen, H.-M., Zhu, Q.-X., Chua, L., Wang, Q.-N., Chia, S.-E., Ong, C.-N. (2003-01-10). The associations among semen quality, oxidative DNA damage in human spermatozoa and concentrations of cadmium, lead and selenium in seminal plasma. Mutation Research - Genetic Toxicology and Environmental Mutagenesis 534 (1-2) : 155-163. ScholarBank@NUS Repository. https://doi.org/10.1016/S1383-5718(02)00274-7
Abstract: To explore the associations among semen quality, oxidative DNA damage in human spermatozoa and concentrations of cadmium, lead and selenium in seminal plasma, 56 non-smoking subjects were asked to collect semen by masturbation into a sterile wide-mouth metal-free plastic container after 3 days of abstinence. The conventional semen parameters were analysed. The concentrations of Cd, Pb and Se in seminal plasma were detected using atomic absorption spectrophotometer. 8-OHdG levels in sperm DNA were measured using HPLC-EC. The results showed that the geometric mean concentrations of Cd, Pb and Se were 0.78, 7.8 and 51.4μg/l, respectively. The geometric mean of 8-OHdG/106 dG was 51.4 (95% CI: 21.5-123.0). A significant inverse correlation exists between Cd and sperm density (r=-0.28, P
Source Title: Mutation Research - Genetic Toxicology and Environmental Mutagenesis
URI: http://scholarbank.nus.edu.sg/handle/10635/113672
ISSN: 13835718
DOI: 10.1016/S1383-5718(02)00274-7
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