Please use this identifier to cite or link to this item: https://doi.org/10.1038/sj.bjc.6602696
Title: Surgery and adjuvant radiotherapy vs concurrent chemoradiotherapy in stage III/IV nonmetastatic squamous cell head and neck cancer: A randomised comparison
Authors: Soo, K.-C.
Tan, E.-H.
Wee, J.
Lim, D.
Tai, B.-C. 
Khoo, M.-L.
Goh, C.
Leong, S.-S.
Tan, T.
Fong, K.-W.
Lu, P.
See, A.
Machin, D.
Keywords: Chemotherapy
Randomised
Squamous cell head and neck cancer
Issue Date: 8-Aug-2005
Citation: Soo, K.-C., Tan, E.-H., Wee, J., Lim, D., Tai, B.-C., Khoo, M.-L., Goh, C., Leong, S.-S., Tan, T., Fong, K.-W., Lu, P., See, A., Machin, D. (2005-08-08). Surgery and adjuvant radiotherapy vs concurrent chemoradiotherapy in stage III/IV nonmetastatic squamous cell head and neck cancer: A randomised comparison. British Journal of Cancer 93 (3) : 279-286. ScholarBank@NUS Repository. https://doi.org/10.1038/sj.bjc.6602696
Abstract: We compared concurrent combination chemotherapy and radiotherapy with surgery and adjuvant radiotherapy in patients with stage III/IV nonmetastatic squamous cell head and neck cancer. Patients with non-nasopharyngeal and nonsalivary resectable squamous cell head and neck cancer were randomised to receive either surgery followed by adjuvant radiotherapy (60 Gy over 30 fractions) or concurrent combination chemotherapy and radiotherapy (66Gy in 33 fractions). Combination chemotherapy comprised two cycles of i.v. cisplatin 20 mg m-2 day-1 and i.v. 5-fluorouracil 1000 mg m -2 day-1, both to run over 96 h given on days 1 and 28 of the radiotherapy. A total of 119 patients were randomised. At a median follow-up of 6 years, there was no significant difference in the 3-year disease-free survival rate between the surgery and concurrent chemoradiotherapy (50 vs 40% respectively). The overall organ preservation rate or avoidance of surgery to primary site was 45%. Those with laryngeal/hypopharyngeal disease subsite had a higher organ-preservation rate than the rest (68 vs 30%). Combination chemotherapy and concurrent irradiation with salvage surgery was not superior to conventional surgery and postoperative radiotherapy for resectable advanced squamous cell head and neck cancer. However, this form of treatment schedule with a view to organ-preservation can be attempted especially for those with laryngeal/hypopharyngeal and possibly oropharyngeal disease subsites. © 2005 Cancer Research.
Source Title: British Journal of Cancer
URI: http://scholarbank.nus.edu.sg/handle/10635/113664
ISSN: 00070920
DOI: 10.1038/sj.bjc.6602696
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