Please use this identifier to cite or link to this item:
|Title:||Surgery and adjuvant radiotherapy vs concurrent chemoradiotherapy in stage III/IV nonmetastatic squamous cell head and neck cancer: A randomised comparison||Authors:||Soo, K.-C.
Squamous cell head and neck cancer
|Issue Date:||8-Aug-2005||Citation:||Soo, K.-C., Tan, E.-H., Wee, J., Lim, D., Tai, B.-C., Khoo, M.-L., Goh, C., Leong, S.-S., Tan, T., Fong, K.-W., Lu, P., See, A., Machin, D. (2005-08-08). Surgery and adjuvant radiotherapy vs concurrent chemoradiotherapy in stage III/IV nonmetastatic squamous cell head and neck cancer: A randomised comparison. British Journal of Cancer 93 (3) : 279-286. ScholarBank@NUS Repository. https://doi.org/10.1038/sj.bjc.6602696||Abstract:||We compared concurrent combination chemotherapy and radiotherapy with surgery and adjuvant radiotherapy in patients with stage III/IV nonmetastatic squamous cell head and neck cancer. Patients with non-nasopharyngeal and nonsalivary resectable squamous cell head and neck cancer were randomised to receive either surgery followed by adjuvant radiotherapy (60 Gy over 30 fractions) or concurrent combination chemotherapy and radiotherapy (66Gy in 33 fractions). Combination chemotherapy comprised two cycles of i.v. cisplatin 20 mg m-2 day-1 and i.v. 5-fluorouracil 1000 mg m -2 day-1, both to run over 96 h given on days 1 and 28 of the radiotherapy. A total of 119 patients were randomised. At a median follow-up of 6 years, there was no significant difference in the 3-year disease-free survival rate between the surgery and concurrent chemoradiotherapy (50 vs 40% respectively). The overall organ preservation rate or avoidance of surgery to primary site was 45%. Those with laryngeal/hypopharyngeal disease subsite had a higher organ-preservation rate than the rest (68 vs 30%). Combination chemotherapy and concurrent irradiation with salvage surgery was not superior to conventional surgery and postoperative radiotherapy for resectable advanced squamous cell head and neck cancer. However, this form of treatment schedule with a view to organ-preservation can be attempted especially for those with laryngeal/hypopharyngeal and possibly oropharyngeal disease subsites. © 2005 Cancer Research.||Source Title:||British Journal of Cancer||URI:||http://scholarbank.nus.edu.sg/handle/10635/113664||ISSN:||00070920||DOI:||10.1038/sj.bjc.6602696|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Nov 22, 2022
WEB OF SCIENCETM
checked on Nov 15, 2022
checked on Nov 24, 2022
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.