Please use this identifier to cite or link to this item: https://doi.org/10.1093/carcin/bgh230
Title: Marine n-3 fatty acid intake, glutathione S-transferase polymorphisms and breast cancer risk in post-menopausal Chinese women in Singapore
Authors: Gago-Dominguez, M.
Castelao, J.E.
Sun, C.-L.
Van Den Berg, D.
Koh, W.-P. 
Lee, H.-P. 
Yu, M.C.
Issue Date: Nov-2004
Citation: Gago-Dominguez, M., Castelao, J.E., Sun, C.-L., Van Den Berg, D., Koh, W.-P., Lee, H.-P., Yu, M.C. (2004-11). Marine n-3 fatty acid intake, glutathione S-transferase polymorphisms and breast cancer risk in post-menopausal Chinese women in Singapore. Carcinogenesis 25 (11) : 2143-2147. ScholarBank@NUS Repository. https://doi.org/10.1093/carcin/bgh230
Abstract: We have previously found marine n-3 fatty acids to be inversely related to post-menopausal breast cancer in Chinese women from Singapore. Post-menopausal women with high [quartiles 2-4 (Q2-Q4)] versus low [quartile 1 (Q1)] intake exhibited a statistically significant reduction in risk of breast cancer after adjustment for potential confounders [relative risk (RR) = 0.66, 95% confidence interval (CI) = 0.50, 0.87]. Experimental studies have demonstrated a direct role for the peroxidation products of marine n-3 fatty acids in breast cancer protection. There is a suggestion that the glutathione S-transferases (GSTs) may be major catalysts in the elimination of these beneficial by-products. Therefore, we hypothesized that individuals possessing the low activity genotypes of GSTM1, GSTT1 and/or GSTP1 (i.e. the GSTM1 null, GSTT1 null and GSTP1 AB/BB genotypes, respectively) may exhibit a stronger marine n-3 fatty acid- breast cancer association than their high activity counterparts. The Singapore Chinese Health Study is a prospective investigation involving 35 298 middle-aged and older women, who were enrolled between April 1993 and December 1998. In this case-control analysis, nested within the Singapore Chinese Health Study, we compared 258 incident breast cancer cases with 670 cohort controls. Overall, breast cancer risk was unrelated to GSTM1 and GSTP1 genotypes. However, the GSTT1 null genotype was associated with a 30% reduced risk of breast cancer [odds ratio (OR) = 0.71, 95% CI = 0.52, 0.96]. Among women with high activity GST genotypes (i.e. GSTM1 positive, GSTT1 positive and GSTP1 AA), no marine n-3 fatty acid--breast cancer relationships were observed in either premenopausal or post-menopausal women at baseline. However, post-menopausal women possessing the combined GSTM1 null and GSTP1 AB/BB genotypes showed a statistically significant reduction in risk after adjustment for potential confounders (Q2-Q4 versus Q1, OR = 0.36, 95% CI = 0.14, 0.94). A similar relationship was observed among women with the combined GSTT1 null and GSTP1 AB/BB genotypes (OR = 0.26, 95% CI = 0.08, 0.78). © Oxford University Press 2004; all rights reserved.
Source Title: Carcinogenesis
URI: http://scholarbank.nus.edu.sg/handle/10635/113543
ISSN: 01433334
DOI: 10.1093/carcin/bgh230
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

34
checked on Oct 29, 2020

WEB OF SCIENCETM
Citations

34
checked on Oct 29, 2020

Page view(s)

72
checked on Oct 23, 2020

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.