Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/113527
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dc.titleInhibition of histone deacetylase 2 increases apoptosis and p21Cip1/WAF1 expression, independent of histone deacetylase 1
dc.contributor.authorHuang, B.H.
dc.contributor.authorLaban, M.
dc.contributor.authorLeung, C.H.-W.
dc.contributor.authorLee, L.
dc.contributor.authorLee, C.K.
dc.contributor.authorSalto-Tellez, M.
dc.contributor.authorRaju, G.C.
dc.contributor.authorHooi, S.C.
dc.date.accessioned2014-12-01T06:55:29Z
dc.date.available2014-12-01T06:55:29Z
dc.date.issued2005-04
dc.identifier.citationHuang, B.H., Laban, M., Leung, C.H.-W., Lee, L., Lee, C.K., Salto-Tellez, M., Raju, G.C., Hooi, S.C. (2005-04). Inhibition of histone deacetylase 2 increases apoptosis and p21Cip1/WAF1 expression, independent of histone deacetylase 1. Cell Death and Differentiation 12 (4) : 395-404. ScholarBank@NUS Repository.
dc.identifier.issn13509047
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/113527
dc.description.abstractHistone deacetylases (HDACs) 1 and 2 share a high degree of homology and coexist within the same protein complexes. Despite their close association, each possesses unique functions. We show that the upregulation of HDAC2 in colorectal cancer occurred early at the polyp stage, was more robust and occurred more frequently than HDAC1. Similarly, while the expression of HDACs1 and 2 were increased in cervical dysplasia and invasive carcinoma, HDAC2 expression showed a clear demarcation of high-intensity staining at the transition region of dysplasia compared to HDAC1. Upon HDAC2 knockdown, cells displayed an increased number of cellular extensions reminiscent of cell differentiation. There was also an increase in apoptosis, associated with increased p21Cip1/WAF1 expression that was independent of p53. These results suggest that HDACs, especially HDAC2, are important enzymes involved in the early events of carcinogenesis, making them candidate markers for tumor progression and targets for cancer therapy. © 2005 Nature Publishing Group All rights reserved.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1038/sj.cdd.4401567
dc.sourceScopus
dc.subjectApoptosis
dc.subjectCancer marker
dc.subjectDifferentiation
dc.subjectHistone deacetylase
dc.subjectP21Cip1/WAF1
dc.subjectTumorigenesis
dc.typeArticle
dc.contributor.departmentPATHOLOGY
dc.description.sourcetitleCell Death and Differentiation
dc.description.volume12
dc.description.issue4
dc.description.page395-404
dc.description.codenCDDIE
dc.identifier.isiut000227680800011
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