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Title: Inhibition of aflatoxin B1-DNA binding and adduct formation by selenium in rats
Authors: Shi, C.-Y.
Chua, S.-C.
Lee, H.-P. 
Ong, C.-N. 
Keywords: Allatoxin B1
DNA adducts
DNA binding
In vivo
Issue Date: 29-Jul-1994
Citation: Shi, C.-Y.,Chua, S.-C.,Lee, H.-P.,Ong, C.-N. (1994-07-29). Inhibition of aflatoxin B1-DNA binding and adduct formation by selenium in rats. Cancer Letters 82 (2) : 203-208. ScholarBank@NUS Repository.
Abstract: The effect of selenium on aflatoxin B1-DNA binding and adduct formation was studied. Male Fischer 344 rats, fed with up to 8 ppm of sodium selenite in drinking water for 8 weeks, were given a single i.p. dose of aflatoxin B1. The rats were killed 24 h later and the amount of AFB1 bound to hepatic DNA and the amount of DNA adducts formed were determined. Selenium pretreatment resulted in a dose-dependent inhibition of AFB1-DNA binding as well as adduct formation. This was accompanied by an increase of reduced glutathione (GSH) in the liver of selenium-treated animals. These results suggest that selenium could effectively inhibit AFB1-induced DNA damage, which may be partially responsible for its anticarcinogenic effect against AFB1. © 1994.
Source Title: Cancer Letters
ISSN: 03043835
Appears in Collections:Staff Publications

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