Please use this identifier to cite or link to this item:
|Title:||In vitro cytotoxic properties of gold(I) and platinum(II) compounds containing asymmetric [2-(methylsulfinyl) ethyl]diphenylarsine and its phosphorus analogue.||Authors:||Chooi, S.Y.M.
|Issue Date:||Jan-1994||Citation:||Chooi, S.Y.M.,Leung, P.-H.,Sim, K.Y.,Tan, K.S.,Kon, O.L. (1994-01). In vitro cytotoxic properties of gold(I) and platinum(II) compounds containing asymmetric [2-(methylsulfinyl) ethyl]diphenylarsine and its phosphorus analogue.. Tetrahedron: Asymmetry 5 (1) : 49-56. ScholarBank@NUS Repository.||Abstract:||The preparation of novel gold(I) compounds [ClAu(Ph2ECH2CH2S(O)Me] (1 for E = As, 2 for E = P) containing the optically active and racemic forms of asymmetric Ph2ECH2CH2S(O)Me ligands is described. In both solid state and solution, the ligands behave as monodentates that coordinate to gold via arsenic or phosphorus. In vitro cytotoxicity evaluation in three human tumour models (Molt 4, Raji and CEM) showed the optically active and racemic forms of 2 to be remarkably potent. With the exception of the CEM tumour cells, (R)- and (S)-2 displayed much higher potency than the corresponding gold-arsine analogues. In contrast, the optically active dichloro-platinum(II) compounds [Cl2Pt(Ph2ECH2CH2S(O)Me] (3 for E = As, 4 for E = P) displayed negligible activities. © 1994.||Source Title:||Tetrahedron: Asymmetry||URI:||http://scholarbank.nus.edu.sg/handle/10635/113517||ISSN:||09574166|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Oct 14, 2021
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.