Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/113517
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dc.titleIn vitro cytotoxic properties of gold(I) and platinum(II) compounds containing asymmetric [2-(methylsulfinyl) ethyl]diphenylarsine and its phosphorus analogue.
dc.contributor.authorChooi, S.Y.M.
dc.contributor.authorLeung, P.-H.
dc.contributor.authorSim, K.Y.
dc.contributor.authorTan, K.S.
dc.contributor.authorKon, O.L.
dc.date.accessioned2014-12-01T06:55:23Z
dc.date.available2014-12-01T06:55:23Z
dc.date.issued1994-01
dc.identifier.citationChooi, S.Y.M.,Leung, P.-H.,Sim, K.Y.,Tan, K.S.,Kon, O.L. (1994-01). In vitro cytotoxic properties of gold(I) and platinum(II) compounds containing asymmetric [2-(methylsulfinyl) ethyl]diphenylarsine and its phosphorus analogue.. Tetrahedron: Asymmetry 5 (1) : 49-56. ScholarBank@NUS Repository.
dc.identifier.issn09574166
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/113517
dc.description.abstractThe preparation of novel gold(I) compounds [ClAu(Ph2ECH2CH2S(O)Me] (1 for E = As, 2 for E = P) containing the optically active and racemic forms of asymmetric Ph2ECH2CH2S(O)Me ligands is described. In both solid state and solution, the ligands behave as monodentates that coordinate to gold via arsenic or phosphorus. In vitro cytotoxicity evaluation in three human tumour models (Molt 4, Raji and CEM) showed the optically active and racemic forms of 2 to be remarkably potent. With the exception of the CEM tumour cells, (R)- and (S)-2 displayed much higher potency than the corresponding gold-arsine analogues. In contrast, the optically active dichloro-platinum(II) compounds [Cl2Pt(Ph2ECH2CH2S(O)Me] (3 for E = As, 4 for E = P) displayed negligible activities. © 1994.
dc.sourceScopus
dc.typeArticle
dc.contributor.departmentCHEMISTRY
dc.contributor.departmentBIOCHEMISTRY
dc.description.sourcetitleTetrahedron: Asymmetry
dc.description.volume5
dc.description.issue1
dc.description.page49-56
dc.description.codenTASYE
dc.identifier.isiutNOT_IN_WOS
Appears in Collections:Staff Publications

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