Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/113482
Title: Familial Risk of Allergic Rhinitis and Atopic Dermatitis among Chinese Families in Singapore
Authors: Lee, J.T.
Lam, Z.C.M.
Lee, W.T.
Kuo, L.C.T.
Jayant, V.
Singh, G.
Lee, J. 
Keywords: Allergic rhinitis
Atopic dermatitis
Atopy
Familial study
Singapore
Issue Date: Jan-2004
Citation: Lee, J.T.,Lam, Z.C.M.,Lee, W.T.,Kuo, L.C.T.,Jayant, V.,Singh, G.,Lee, J. (2004-01). Familial Risk of Allergic Rhinitis and Atopic Dermatitis among Chinese Families in Singapore. Annals of the Academy of Medicine Singapore 33 (1) : 71-74. ScholarBank@NUS Repository.
Abstract: Introduction: This study aims to determine the familial risk of atopic dermatitis (AD) and allergic rhinitis (AR) in Chinese children. Materials and Methods: A cross-sectional study was conducted in a housing estate in Singapore. Data was collected using an interviewer-administered questionnaire. Participants included 257 Chinese families. Prevalence rate ratios (PRRs) and 95% confidence interval (CI) were calculated. Results: For AD in all children, an increasing trend was found with PRRs of 1.9(95% CI, 0.3 to 11.8) and 1.5 (95% CI, 0.4 to 5.5) for only father and only mother affected, respectively, to 2.3 (95% CI, 0.4 to 13.7) for both parents affected. In AR, a PRR of 2.7 (95% CI, 1.8 to 3.9) and 2.2 (95% CI, 1.5 to 3.2) for only father and only mother affected, respectively, and 4.5 (95% CI, 3.3 to 6.1) for both affected was found. The PRR (2.2; 95% CI, 1.4 to 3.7) of the first child developing AR when paternal or maternal history was positive was similar. This rose to 3.4 (95% CI, 2.2 to 5.1) when both parents also had AR. The PRR of the second child developing AR was 3.9 (95% CI, 1.7 to 8.9) when the first child alone was positive for AR and 7.0 (95% CI, 3.5 to 13.9) when both parents and the eldest child had AR. Conclusion: A positive family history increases the risk of developing AD and AR with increasing risk dependent on number of relatives affected. The second child's risk of AR is also associated with AR in the first child, suggesting mechanisms of incomplete penetrance.
Source Title: Annals of the Academy of Medicine Singapore
URI: http://scholarbank.nus.edu.sg/handle/10635/113482
ISSN: 03044602
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

Page view(s)

47
checked on Mar 28, 2020

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.