Please use this identifier to cite or link to this item: https://doi.org/10.1007/s10620-012-2528-2
Title: Factors determining diagnostic yield of endoscopic ultrasound guided fine-needle aspiration for pancreatic cystic lesions: A multicentre Asian study
Authors: Lim, L.G.
Lakhtakia, S.
Ang, T.L.
Vu, C.K.F.
Dy, F.
Chong, V.H.
Khor, C.J.L.
Lim, W.C.
Doshi, B.K.
Varadarajulu, S.
Yasuda, K.
Wong, J.Y.Y. 
Chan, Y.H.
Nga, M.E.
Ho, K.Y.
Keywords: Diagnostic yield
Endoscopic ultrasound
Fine-needle aspiration
Pancreatic cysts
Issue Date: Jun-2013
Citation: Lim, L.G., Lakhtakia, S., Ang, T.L., Vu, C.K.F., Dy, F., Chong, V.H., Khor, C.J.L., Lim, W.C., Doshi, B.K., Varadarajulu, S., Yasuda, K., Wong, J.Y.Y., Chan, Y.H., Nga, M.E., Ho, K.Y. (2013-06). Factors determining diagnostic yield of endoscopic ultrasound guided fine-needle aspiration for pancreatic cystic lesions: A multicentre Asian study. Digestive Diseases and Sciences 58 (6) : 1751-1757. ScholarBank@NUS Repository. https://doi.org/10.1007/s10620-012-2528-2
Abstract: Background and Aim: The purpose of this study was to determine (1) the diagnostic yield for endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) in patients with pancreatic cystic lesions, (2) additional value of EUS-FNA over EUS alone in the diagnosis of pancreatic cysts, and (3) diagnostic sensitivity and specificity of EUS and EUS-FNA in the subset of patients where histopathology of surgical specimens were available. Methods: All patients who underwent EUS examination for the evaluation of pancreatic cystic lesions in six Asian centres were included in the study. Results: Of 298 patients with pancreatic cysts who underwent EUS, 132 (44.3 %) underwent FNA. In the entire cohort, pseudocysts and intraductal papillary mucinous neoplasm (IPMN) were the predominant cystic lesions. The cytologic yield of EUS-FNA was 47 %. On univariate analysis, factors associated with higher cytologic yield included vascular involvement on EUS, presence of solid cystic component, and increased number of needle passes during EUS-FNA. On multivariate analysis, presence of solid cystic components and increased number of needle passes during EUS-FNA were associated with higher diagnostic yield of EUS-FNA. For pancreatic cysts with a solid component, the diagnostic yield of EUS-FNA increased significantly from 44 % with one pass to 78 % with more than one pass (p = 0.016). In the absence of a solid component, the diagnostic yield was 29 % with one pass and was not significantly different from the diagnostic yield of 50 % with more than one pass, p = 0.081. Conclusion: The cytologic yield of EUS-FNA was 47 %. When a solid component was present in the cyst, doing more than one pass during EUS-FNA increased its diagnostic yield. © 2013 Springer Science+Business Media New York.
Source Title: Digestive Diseases and Sciences
URI: http://scholarbank.nus.edu.sg/handle/10635/113479
ISSN: 01632116
DOI: 10.1007/s10620-012-2528-2
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