Please use this identifier to cite or link to this item:
https://doi.org/10.1016/j.devcel.2005.03.015
DC Field | Value | |
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dc.title | Echinoid is a component of adherens junctions that cooperates with DE-cadherin to mediate cell adhesion | |
dc.contributor.author | Wei, S.-Y. | |
dc.contributor.author | Escudero, L.M. | |
dc.contributor.author | Yu, F. | |
dc.contributor.author | Chang, L.H. | |
dc.contributor.author | Chen, L.-Y. | |
dc.contributor.author | Ho, Y.-H. | |
dc.contributor.author | Lin, C.-M. | |
dc.contributor.author | Chou, C.-S. | |
dc.contributor.author | Chia, W. | |
dc.contributor.author | Modolell, J. | |
dc.contributor.author | Hsu, J.-C. | |
dc.date.accessioned | 2014-12-01T06:54:38Z | |
dc.date.available | 2014-12-01T06:54:38Z | |
dc.date.issued | 2005-04 | |
dc.identifier.citation | Wei, S.-Y., Escudero, L.M., Yu, F., Chang, L.H., Chen, L.-Y., Ho, Y.-H., Lin, C.-M., Chou, C.-S., Chia, W., Modolell, J., Hsu, J.-C. (2005-04). Echinoid is a component of adherens junctions that cooperates with DE-cadherin to mediate cell adhesion. Developmental Cell 8 (4) : 493-504. ScholarBank@NUS Repository. https://doi.org/10.1016/j.devcel.2005.03.015 | |
dc.identifier.issn | 15345807 | |
dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/113449 | |
dc.description.abstract | Echinoid is an immunoglobulin domain-containing transmembrane protein that modulates cell-cell signaling by Notch and the EGF receptors. We show that, in the Drosophila wing disc epithelium, Echinoid is a component of adherens junctions that cooperates with DE-Cadherin in cell adhesion. Echinoid and β-catenin (a DE-Cadherin interacting protein) each possess a C-terminal PDZ domain binding motif that binds to Bazooka/PAR-3; these motifs redundantly position Bazooka to adherens junctions. Echinoid also links to actin filaments by binding to Canoe/AF-6/afadin. Moreover, interfaces between Echinoid- and Echinoid+ cells, like those between DE-Cadherin- and DE-Cadherin+ cells, are deficient in adherens junctions and form actin cables. These characteristics probably facilitate the strong sorting behavior of cells that lack either of these cell-adhesion molecules. Finally, cells lacking either Echinoid or DE-Cadherin accumulate a high density of the reciprocal protein, further suggesting that Echinoid and DE-Cadherin play similar and complementary roles in cell adhesion. Copyright © 2005 by Elsevier Inc. | |
dc.description.uri | http://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.devcel.2005.03.015 | |
dc.source | Scopus | |
dc.type | Article | |
dc.contributor.department | DEAN'S OFFICE (MEDICINE) | |
dc.contributor.department | BIOLOGICAL SCIENCES | |
dc.description.doi | 10.1016/j.devcel.2005.03.015 | |
dc.description.sourcetitle | Developmental Cell | |
dc.description.volume | 8 | |
dc.description.issue | 4 | |
dc.description.page | 493-504 | |
dc.description.coden | DCEEB | |
dc.identifier.isiut | 000228435600009 | |
Appears in Collections: | Staff Publications |
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