Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.devcel.2005.03.015
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dc.titleEchinoid is a component of adherens junctions that cooperates with DE-cadherin to mediate cell adhesion
dc.contributor.authorWei, S.-Y.
dc.contributor.authorEscudero, L.M.
dc.contributor.authorYu, F.
dc.contributor.authorChang, L.H.
dc.contributor.authorChen, L.-Y.
dc.contributor.authorHo, Y.-H.
dc.contributor.authorLin, C.-M.
dc.contributor.authorChou, C.-S.
dc.contributor.authorChia, W.
dc.contributor.authorModolell, J.
dc.contributor.authorHsu, J.-C.
dc.date.accessioned2014-12-01T06:54:38Z
dc.date.available2014-12-01T06:54:38Z
dc.date.issued2005-04
dc.identifier.citationWei, S.-Y., Escudero, L.M., Yu, F., Chang, L.H., Chen, L.-Y., Ho, Y.-H., Lin, C.-M., Chou, C.-S., Chia, W., Modolell, J., Hsu, J.-C. (2005-04). Echinoid is a component of adherens junctions that cooperates with DE-cadherin to mediate cell adhesion. Developmental Cell 8 (4) : 493-504. ScholarBank@NUS Repository. https://doi.org/10.1016/j.devcel.2005.03.015
dc.identifier.issn15345807
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/113449
dc.description.abstractEchinoid is an immunoglobulin domain-containing transmembrane protein that modulates cell-cell signaling by Notch and the EGF receptors. We show that, in the Drosophila wing disc epithelium, Echinoid is a component of adherens junctions that cooperates with DE-Cadherin in cell adhesion. Echinoid and β-catenin (a DE-Cadherin interacting protein) each possess a C-terminal PDZ domain binding motif that binds to Bazooka/PAR-3; these motifs redundantly position Bazooka to adherens junctions. Echinoid also links to actin filaments by binding to Canoe/AF-6/afadin. Moreover, interfaces between Echinoid- and Echinoid+ cells, like those between DE-Cadherin- and DE-Cadherin+ cells, are deficient in adherens junctions and form actin cables. These characteristics probably facilitate the strong sorting behavior of cells that lack either of these cell-adhesion molecules. Finally, cells lacking either Echinoid or DE-Cadherin accumulate a high density of the reciprocal protein, further suggesting that Echinoid and DE-Cadherin play similar and complementary roles in cell adhesion. Copyright © 2005 by Elsevier Inc.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.devcel.2005.03.015
dc.sourceScopus
dc.typeArticle
dc.contributor.departmentDEAN'S OFFICE (MEDICINE)
dc.contributor.departmentBIOLOGICAL SCIENCES
dc.description.doi10.1016/j.devcel.2005.03.015
dc.description.sourcetitleDevelopmental Cell
dc.description.volume8
dc.description.issue4
dc.description.page493-504
dc.description.codenDCEEB
dc.identifier.isiut000228435600009
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