Please use this identifier to cite or link to this item:
https://scholarbank.nus.edu.sg/handle/10635/113435
DC Field | Value | |
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dc.title | Developmental activation of calmodulin-dependent facilitation of cerebellar P-type Ca2+ current | |
dc.contributor.author | Chaudhuri, D. | |
dc.contributor.author | Alseikhan, B.A. | |
dc.contributor.author | Chang, S.Y. | |
dc.contributor.author | Soong, T.W. | |
dc.contributor.author | Yue, D.T. | |
dc.date.accessioned | 2014-12-01T06:54:26Z | |
dc.date.available | 2014-12-01T06:54:26Z | |
dc.date.issued | 2005-09-07 | |
dc.identifier.citation | Chaudhuri, D., Alseikhan, B.A., Chang, S.Y., Soong, T.W., Yue, D.T. (2005-09-07). Developmental activation of calmodulin-dependent facilitation of cerebellar P-type Ca2+ current. Journal of Neuroscience 25 (36) : 8282-8294. ScholarBank@NUS Repository. | |
dc.identifier.issn | 02706474 | |
dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/113435 | |
dc.description.abstract | P-type (Cav2.1) Ca2+ channels are a central conduit of neuronal Ca2+ entry, so their Ca2+ feedback regulation promises widespread neurobiological impact. Heterologous expression of recombinant Cav2.1 channels demonstrates that the Ca2+ sensor calmodulin can trigger Ca2+-dependent facilitation (CDF) of channel opening. This facilitation occurs when local Ca2+ influx through individual channels selectively activates the C-terminal lobe of calmodulin. In neurons, however, such calmodulin-mediated processes have yet to be detected, and CDF of native P-type current has thus far appeared different, arguably triggered by other Ca2+ sensing molecules. Here, in cerebellar Purkinje somata abundant with prototypic P-type channels, we find that the C-terminal lobe of calmodulin does produce CDF, and such facilitation augments Ca2+ entry during stimulation by repetitive action-potential and complex-spike waveforms. Beyond recapitulating key features of recombinant channels, these neurons exhibit an additional modulatory dimension: developmental upregulation of CDF during postnatal week 2. This phenomenon reflects increasing somatic expression of Cav2.1 splice variants that manifest CDF and progressive dendritic targeting of variants lacking CDF. Calmodulin-triggered facilitation is thus fundamental to native Ca v2.1 and rapidly enhanced during early development. Copyright © 2005 Society for Neuroscience. | |
dc.description.uri | http://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1523/JNEUROSCI.2253-05.2005 | |
dc.source | Scopus | |
dc.subject | α1A | |
dc.subject | Alternative splicing | |
dc.subject | Cerebellar Purkinje neuron | |
dc.subject | EF hand | |
dc.subject | P/Q-type channel | |
dc.subject | Short-term synaptic plasticity | |
dc.type | Article | |
dc.contributor.department | PHYSIOLOGY | |
dc.description.sourcetitle | Journal of Neuroscience | |
dc.description.volume | 25 | |
dc.description.issue | 36 | |
dc.description.page | 8282-8294 | |
dc.description.coden | JNRSD | |
dc.identifier.isiut | 000231718600018 | |
Appears in Collections: | Staff Publications |
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