Please use this identifier to cite or link to this item: https://doi.org/10.1093/carcin/bgh151
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dc.titleChemopreventive activity of parthenolide against UVB-induced skin cancer and its mechanisms
dc.contributor.authorWon, Y.K.
dc.contributor.authorOng, C.-N.
dc.contributor.authorShi, X.
dc.contributor.authorShen, H.-M.
dc.date.accessioned2014-12-01T06:54:01Z
dc.date.available2014-12-01T06:54:01Z
dc.date.issued2004-08
dc.identifier.citationWon, Y.K., Ong, C.-N., Shi, X., Shen, H.-M. (2004-08). Chemopreventive activity of parthenolide against UVB-induced skin cancer and its mechanisms. Carcinogenesis 25 (8) : 1449-1458. ScholarBank@NUS Repository. https://doi.org/10.1093/carcin/bgh151
dc.identifier.issn01433334
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/113396
dc.description.abstractParthenolide (PN) is a major sesquiterpene lactone of feverfew (Tanacetum parthanium) with known anti-inflammatory activity. However, the anticancer effects of PN have not been well studied. In the present investigation, we examined the cancer chemopreventive property of PN using a combination of in vivo and in vitro approaches. We first tested the anticancer effect of PN in UVB-induced skin cancer model. Mice fed with PN (1 mg/day) showed a delayed onset of papilloma incidence, a significant reduction in papilloma multiplicity (papilloma/mouse) and sizes when compared with the UVB-only group. To our surprise, neither PN nor the known cyclooxygenase (COX)-2 inhibitor celecoxib inhibit UVB-induced COX-2 expression and epidermal prostaglandin E2 (PGE2) production. We next investigated the molecular mechanism(s) involved in its anticancer effects using cultured JB6 murine epidermal cells. Non-cytotoxic concentrations of PN significantly inhibited UVB-induced activator protein-1 DNA binding and transcriptional activity. In addition, PN pre-treatment also inhibited c-Jun-N-terminal kinase (JNK) and p38 kinase activation. More importantly, we found that impaired AP-1, JNK and p38 signaling led to the sensitization of JB6 cells to UVB-induced apoptosis. Data from our study for the first time confirm the anticancer property of PN in an animal model, and provide evidence that the inhibitory effects on AP-1 and mitogen-activated protein kinases serve as one of the underlying mechanisms for the cancer chemopreventive property of PN. © Oxford University Press 2004; all rights reserved.
dc.sourceScopus
dc.typeArticle
dc.contributor.departmentCOMMUNITY,OCCUPATIONAL & FAMILY MEDICINE
dc.description.doi10.1093/carcin/bgh151
dc.description.sourcetitleCarcinogenesis
dc.description.volume25
dc.description.issue8
dc.description.page1449-1458
dc.description.codenCRNGD
dc.identifier.isiut000223142700017
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