Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/113354
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dc.titleAlternative splicing as a molecular switch for Ca2+/calmodulin- dependent facilitation of P/Q-type Ca2+ channels
dc.contributor.authorChaudhuri, D.
dc.contributor.authorChang, S.-Y.
dc.contributor.authorDeMaria, C.D.
dc.contributor.authorAlvania, R.S.
dc.contributor.authorSoong, T.W.
dc.contributor.authorYue, D.T.
dc.date.accessioned2014-12-01T06:53:32Z
dc.date.available2014-12-01T06:53:32Z
dc.date.issued2004-07-14
dc.identifier.citationChaudhuri, D., Chang, S.-Y., DeMaria, C.D., Alvania, R.S., Soong, T.W., Yue, D.T. (2004-07-14). Alternative splicing as a molecular switch for Ca2+/calmodulin- dependent facilitation of P/Q-type Ca2+ channels. Journal of Neuroscience 24 (28) : 6334-6342. ScholarBank@NUS Repository.
dc.identifier.issn02706474
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/113354
dc.description.abstractAlternative splicing of the P/Q-type channel (Cav2.1) promises customization of the computational repertoire of neurons. Here we report that concerted splicing of its main α1A subunit, at both an EF-hand-like domain and the channel C terminus, controls the form of Ca 2+-dependent facilitation (CDF), an activity-dependent enhancement of channel opening that is triggered by calmodulin. In recombinant channels, such alternative splicing switches CDF among three modes: (1) completely "ON" and driven by local Ca2+ influx through individual channels, (2) completely "OFF," and (3) partially OFF but inducible by elevated global Ca2+ influx. Conversion from modes 1 to 3 represents an unprecedented dimension of control. The physiological function of these variants is likely important, because we find that the distribution of EF-hand splice variants is strikingly heterogeneous in the human brain, varying both across regions and during development.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1523/JNEUROSCI.1712-04.2004
dc.sourceScopus
dc.subjectCa 2+-dependent inactivation
dc.subjectCav2.1
dc.subjectDevelopmental alternative splicing
dc.subjectEF hand
dc.subjectExon 37
dc.subjectShort-term synaptic plasticity
dc.typeArticle
dc.contributor.departmentPHYSIOLOGY
dc.description.sourcetitleJournal of Neuroscience
dc.description.volume24
dc.description.issue28
dc.description.page6334-6342
dc.description.codenJNRSD
dc.identifier.isiut000222650000012
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