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|Title:||Alternative splicing as a molecular switch for Ca2+/calmodulin- dependent facilitation of P/Q-type Ca2+ channels||Authors:||Chaudhuri, D.
|Keywords:||Ca 2+-dependent inactivation
Developmental alternative splicing
Short-term synaptic plasticity
|Issue Date:||14-Jul-2004||Citation:||Chaudhuri, D., Chang, S.-Y., DeMaria, C.D., Alvania, R.S., Soong, T.W., Yue, D.T. (2004-07-14). Alternative splicing as a molecular switch for Ca2+/calmodulin- dependent facilitation of P/Q-type Ca2+ channels. Journal of Neuroscience 24 (28) : 6334-6342. ScholarBank@NUS Repository.||Abstract:||Alternative splicing of the P/Q-type channel (Cav2.1) promises customization of the computational repertoire of neurons. Here we report that concerted splicing of its main α1A subunit, at both an EF-hand-like domain and the channel C terminus, controls the form of Ca 2+-dependent facilitation (CDF), an activity-dependent enhancement of channel opening that is triggered by calmodulin. In recombinant channels, such alternative splicing switches CDF among three modes: (1) completely "ON" and driven by local Ca2+ influx through individual channels, (2) completely "OFF," and (3) partially OFF but inducible by elevated global Ca2+ influx. Conversion from modes 1 to 3 represents an unprecedented dimension of control. The physiological function of these variants is likely important, because we find that the distribution of EF-hand splice variants is strikingly heterogeneous in the human brain, varying both across regions and during development.||Source Title:||Journal of Neuroscience||URI:||http://scholarbank.nus.edu.sg/handle/10635/113354||ISSN:||02706474|
|Appears in Collections:||Staff Publications|
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