Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/113354
Title: Alternative splicing as a molecular switch for Ca2+/calmodulin- dependent facilitation of P/Q-type Ca2+ channels
Authors: Chaudhuri, D.
Chang, S.-Y.
DeMaria, C.D.
Alvania, R.S.
Soong, T.W. 
Yue, D.T.
Keywords: Ca 2+-dependent inactivation
Cav2.1
Developmental alternative splicing
EF hand
Exon 37
Short-term synaptic plasticity
Issue Date: 14-Jul-2004
Citation: Chaudhuri, D., Chang, S.-Y., DeMaria, C.D., Alvania, R.S., Soong, T.W., Yue, D.T. (2004-07-14). Alternative splicing as a molecular switch for Ca2+/calmodulin- dependent facilitation of P/Q-type Ca2+ channels. Journal of Neuroscience 24 (28) : 6334-6342. ScholarBank@NUS Repository.
Abstract: Alternative splicing of the P/Q-type channel (Cav2.1) promises customization of the computational repertoire of neurons. Here we report that concerted splicing of its main α1A subunit, at both an EF-hand-like domain and the channel C terminus, controls the form of Ca 2+-dependent facilitation (CDF), an activity-dependent enhancement of channel opening that is triggered by calmodulin. In recombinant channels, such alternative splicing switches CDF among three modes: (1) completely "ON" and driven by local Ca2+ influx through individual channels, (2) completely "OFF," and (3) partially OFF but inducible by elevated global Ca2+ influx. Conversion from modes 1 to 3 represents an unprecedented dimension of control. The physiological function of these variants is likely important, because we find that the distribution of EF-hand splice variants is strikingly heterogeneous in the human brain, varying both across regions and during development.
Source Title: Journal of Neuroscience
URI: http://scholarbank.nus.edu.sg/handle/10635/113354
ISSN: 02706474
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

62
checked on Feb 28, 2018

WEB OF SCIENCETM
Citations

56
checked on Dec 31, 2018

Page view(s)

62
checked on May 21, 2019

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.