Please use this identifier to cite or link to this item:
Title: Alpha coat protein COPA (HEP-COP): Presence of an Alu repeat in cDNA and identity of the amino terminus to xenin
Authors: Chow, V.T.K.
Quek, H.H. 
Issue Date: Jul-1997
Citation: Chow, V.T.K., Quek, H.H. (1997-07). Alpha coat protein COPA (HEP-COP): Presence of an Alu repeat in cDNA and identity of the amino terminus to xenin. Annals of Human Genetics 61 (4) : 369-373. ScholarBank@NUS Repository.
Abstract: We previously sequenced the 4333-nucleotide cDNA of the COPA (HEP-COP) gene which encodes the human homologue of the α-subunit of the coatomer protein complex, involved in intracellular protein transport. Within the 3' untranslated region at nucleotides 4049-4333 was observed an Alu repeat containing conserved A and B block elements, and showing high homology to the human Alu-Sx subfamily consensus sequence. Upstream of the Alu repeat were noted a TATA box, a CAAT motif and two activating transcription factor (ATF)-like binding sites, which represent putative regulatory elements directing Alu transcription. In addition, the 25 and 35 N-terminal amino acid residues of COPA and its bovine homologue were identical to xenin-25 and proxenin, respectively. Xenin-25 is a gastrointestinal hormone that stimulates exocrine pancreatic secretion. This peptide is related to xenopsin, neurotensin and neuromedin N which are bioactive peptides derived from larger precursors via proteolytic cleavage by cathepsin E at processing sites determined by conserved C-terminal sequences, i.e. proline/valine-X-X-hydrophobic amino acid. Given the conformity of the C-terminal residues of xenin-25 (PWIL) and of its progenitor molecule, proxenin (VIQL), it is proposed that these peptides are generated by a similar mechanism of post-translational modification involving a parent precursor represented by the α-subunit of coatomer.
Source Title: Annals of Human Genetics
ISSN: 00034800
DOI: 10.1017/S0003480097006295
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.


checked on Feb 2, 2023


checked on Feb 2, 2023

Page view(s)

checked on Feb 2, 2023

Google ScholarTM



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.